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Proceedings Paper

Fluorescence photodetection of urothelial neoplastic foci in superficial bladder cancer
Author(s): Patrice Jichlinski; Martin Forrer; Jerome C. Mizeret; Daniel Braichotte; Georges A. Wagnieres; Georges Zimmer; Louis Guillou; Franz R. Schmidlin; Peter Graber; Hubert van den Bergh; Hans-Juerg Leisinger
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Paper Abstract

The prognosis of superficial bladder cancer in terms of recurrence and disease progression is related to the bladder tumor multiplicity and the presence of concomitant 'plane' tumors such as high grade dysplasia and carcinoma in situ (CIS). This study on 33 patients tries to demonstrate the interest of fluorescence cystoscopy in transurethral resection of superficial bladder cancer The method is based on the detection of the protoporphyrin IX (PpIX) induced fluorescence in urothelial cancer cells by topical administration of 5- aminolevulinic acid (ALA). The sensitivity and the specificity of this procedure on apparently normal mucosa in superficial bladder cancer is respectively estimated at 82.9% and 81.3%. Thus, fluorescence cystoscopy is a simple and reliable method in mapping the bladder mucosa, especially in case of multifocal bladder disease and it facilitates the screening of occult dysplasia.

Paper Details

Date Published: 22 May 1997
PDF: 5 pages
Proc. SPIE 2970, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VII, (22 May 1997); doi: 10.1117/12.275078
Show Author Affiliations
Patrice Jichlinski, Ctr. Hospitalier Universitaire Vaudois (Switzerland)
Martin Forrer, Swiss Federal Institute of Technology (Switzerland)
Jerome C. Mizeret, Swiss Federal Institute of Technology (Switzerland)
Daniel Braichotte, Swiss Federal Institute of Technology (Switzerland)
Georges A. Wagnieres, Swiss Federal Institute of Technology (Switzerland)
Georges Zimmer, Ctr. Hospitalier Universitaire Vaudois (Switzerland)
Louis Guillou, Ctr. Hospitalier Universitaire Vaudois (Switzerland)
Franz R. Schmidlin, Ctr. Hospitalier Universitaire Geneve (Switzerland)
Peter Graber, Ctr. Hospitalier Universitaire Geneve (Switzerland)
Hubert van den Bergh, Swiss Federal Institute of Technology (Switzerland)
Hans-Juerg Leisinger, Ctr. Hospitalier Universitaire Vaudois (Switzerland)

Published in SPIE Proceedings Vol. 2970:
Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VII
R. Rox Anderson; Harvey Lui; Michail M. Pankratov; Kenneth Eugene Bartels; Gerhard J. Mueller; Graham M. Watson; Reza S. Malek; Lawrence S. Bass; Lloyd P. Tate; Hans-Dieter Reidenbach; Kenneth Eugene Bartels; R. Rox Anderson; Lawrence S. Bass; Aaron P. Perlmutter; Kenton W. Gregory; David M. Harris; David M. Harris; Harvey Lui; Reza S. Malek; Gerhard J. Mueller; Michail M. Pankratov; Aaron P. Perlmutter; Hans-Dieter Reidenbach; Lloyd P. Tate; Graham M. Watson, Editor(s)

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