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Morphological changes after Nd:YAG laser treatment of the human prostate with the SideFocus fiber: correlation to MRI and impact of dosimetry and time
Author(s): Tullio Sulser; Wolfram Jochum; Rahel Huch Boni; Gabriel P. Krestin; Philipp U. Heitz; Dieter Hauri
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Paper Abstract

Determination of optimal treatment parameters and appropriate methods of examination for Nd:YAG laser coagulation of the human prostate in dependence of power-setting and time using the SideFocusR side-firing delivery system. Transurethral free-beam laser coagulation was performed in 10 patients prior to planned radical prostatectomy. Thereof 6 underwent laparoscopic lymphadenectomy and laser coagulation of the prostate between 4 and 9 days prior to open surgery. These same patients had undergone MRI-examination with an endorectal coil during staging and prior to radical prostatectomy. Depth and volume of coagulated prostatic tissue of a 4-quadrant laser application were measured at power settings of 40 W/90 s and 60 W/60 s. There was no difference in volume coagulation between the two treatment modalities. In contrast there was a significant difference in volume coagulation between those prostates removed at 4 to 9 days and those removed t 60 to 210 minutes after laser coagulation. In histological and MRI- examination, however, there was a strong correlation with view to coagulation volume. Both treatment modalities showed comparable volume coagulation with laser induced changes conclusively discernible by 4 days. MRI-examination with an endorectal coil proved to be perfectly suitable for assessment.

Paper Details

Date Published: 22 May 1997
PDF: 9 pages
Proc. SPIE 2970, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VII, (22 May 1997); doi: 10.1117/12.275070
Show Author Affiliations
Tullio Sulser, Univ. Hospital Zurich (Switzerland)
Wolfram Jochum, Univ. Hospital Zurich (Switzerland)
Rahel Huch Boni, Univ. Hospital Zurich (Switzerland)
Gabriel P. Krestin, Univ. Hospital Zurich (Switzerland)
Philipp U. Heitz, Univ. Hospital Zurich (Switzerland)
Dieter Hauri, Univ. Hospital Zurich (Switzerland)


Published in SPIE Proceedings Vol. 2970:
Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VII
R. Rox Anderson; Kenneth Eugene Bartels; Lawrence S. Bass; Kenton W. Gregory; David M. Harris; Harvey Lui; Reza S. Malek; Gerhard J. Mueller; Michail M. Pankratov; Aaron P. Perlmutter; Hans-Dieter Reidenbach; Lloyd P. Tate; Graham M. Watson; Harvey Lui; Lawrence S. Bass; R. Rox Anderson; David M. Harris; Michail M. Pankratov; Kenneth Eugene Bartels; Lloyd P. Tate; Gerhard J. Mueller; Hans-Dieter Reidenbach; Graham M. Watson; Reza S. Malek; Aaron P. Perlmutter, Editor(s)

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