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Proceedings Paper

Er:YAG laser-induced changes in skin in vivo and transdermal drug delivery
Author(s): Stephen Thomas Flock; Tom Stern; Paul Lehman; Scott Dinehart M.D.; Tom Franz; George Liu; Scott J. Stern M.D.
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Paper Abstract

It has been shown that laser ablation of stratum corneum, in vitro, can result in an increased uptake of topically applied pharmaceuticals. We have performed measurements of drug permeation, using an in vitro model of human skin, that involves a portable Er:YAG laser used to ablate the stratum corneum. For the first time, this method of drug administration was tested in vivo in human volunteers, whereby a hydrocortisone blanching assay was used to assess the efficiency of the procedure. The results show that this is a safe and efficient way to ablate stratum corneum for the purpose of enhanced transcutaneous drug administration.

Paper Details

Date Published: 22 May 1997
PDF: 6 pages
Proc. SPIE 2970, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VII, (22 May 1997); doi: 10.1117/12.275068
Show Author Affiliations
Stephen Thomas Flock, Univ. of Arkansas for Medical Sciences (United States)
Tom Stern, Univ. of Arkansas for Medical Sciences (United States)
Paul Lehman, Univ. of Arkansas for Medical Sciences (United States)
Scott Dinehart M.D., Univ. of Arkansas for Medical Sciences (United States)
Tom Franz, Univ. of Arkansas for Medical Sciences (United States)
George Liu, Univ. of Arkansas for Medical Sciences (United States)
Scott J. Stern M.D., Univ. of Arkansas for Medical Sciences (United States)


Published in SPIE Proceedings Vol. 2970:
Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VII
R. Rox Anderson M.D.; Harvey Lui M.D.; Michail M. Pankratov; Kenneth Eugene Bartels D.V.M.; Gerhard J. Mueller; Graham M. Watson M.D.; Reza S. Malek M.D.; Lawrence S. Bass M.D.; Lloyd P. Tate V.D.M.; Hans-Dieter Reidenbach; Kenneth Eugene Bartels D.V.M.; R. Rox Anderson M.D.; Lawrence S. Bass M.D.; Aaron P. Perlmutter M.D.; Kenton W. Gregory M.D.; David M. Harris; David M. Harris; Harvey Lui M.D.; Reza S. Malek M.D.; Gerhard J. Mueller; Michail M. Pankratov; Aaron P. Perlmutter M.D.; Hans-Dieter Reidenbach; Lloyd P. Tate V.D.M.; Graham M. Watson M.D., Editor(s)

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