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Proceedings Paper

Nonablative laser treatment of facial rhytides
Author(s): Gary P. Lask M.D.; Patrick K. Lee; Manouchehr Seyfzadeh M.D.; J. Stuart Nelson M.D.; Thomas E. Milner; Bahman Anvari; Digant P. Dave; Roy G. Geronemus; Leonard J. Bernstein; Harry Mittelman; Laurie A. Ridener; Walter F. Coulson M.D.; Bruce Sand; Jon Baumgarder; David R. Hennings; Richard F. Menefee; Michael J. Berry
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Paper Abstract

The purpose of this study is to evaluate the safety and effectiveness of the New Star Model 130 neodymium:yttrium aluminum garnet (Nd:YAG) laser system for nonablative laser treatment of facial rhytides (e.g., periorbital wrinkles). Facial rhytides are treated with 1.32 micrometer wavelength laser light delivered through a fiberoptic handpiece into a 5 mm diameter spot using three 300 microsecond duration pulses at 100 Hz pulse repetition frequency and pulse radiant exposures extending up to 12 J/cm2. Dynamic cooling is used to cool the epidermis selectively prior to laser treatment; animal histology experiments confirm that dynamic cooling combined with nonablative laser heating protects the epidermis and selectively injures the dermis. In the human clinical study, immediately post-treatment, treated sites exhibit mild erythema and, in a few cases, edema or small blisters. There are no long-term complications such as marked dyspigmentation and persistent erythema that are commonly observed following ablative laser skin resurfacing. Preliminary results indicate that the severity of facial rhytides has been reduced, but long-term follow-up examinations are needed to quantify the reduction. The mechanism of action of this nonablative laser treatment modality may involve dermal wound healing that leads to long- term synthesis of new collagen and extracellular matrix material.

Paper Details

Date Published: 22 May 1997
PDF: 12 pages
Proc. SPIE 2970, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VII, (22 May 1997); doi: 10.1117/12.275064
Show Author Affiliations
Gary P. Lask M.D., UCLA Dermatology Laser Surgery Ctr. (United States)
Patrick K. Lee, UCLA Dermatology Laser Surgery Ctr. (United States)
Manouchehr Seyfzadeh M.D., UCLA Dermatology Laser Surgery Ctr. (United States)
J. Stuart Nelson M.D., Univ. of California/Irvine (United States)
Thomas E. Milner, Beckman Laser Institute and Medical Clinic (United States)
Bahman Anvari, Beckman Laser Institute and Medical Clinic and Harvey Mudd College (United States)
Digant P. Dave, Beckman Laser Institute and Medical Clinic (United States)
Roy G. Geronemus, New York Univ. Medical Ctr. (United States)
Leonard J. Bernstein, Laser and Skin Surgery Ctr. of New York (United States)
Harry Mittelman
Laurie A. Ridener, Buckman Co. (United States)
Walter F. Coulson M.D., UCLA Ctr. for Health Sciences (United States)
Bruce Sand, Laser Aesthetics, Inc. (United States)
Jon Baumgarder, Laser Aesthetics, Inc. (United States)
David R. Hennings, New Star Lasers, Inc. (United States)
Richard F. Menefee, New Star Lasers, Inc. (United States)
Michael J. Berry, New Star Lasers, Inc. (United States)


Published in SPIE Proceedings Vol. 2970:
Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VII
R. Rox Anderson M.D.; Harvey Lui M.D.; Michail M. Pankratov; Kenneth Eugene Bartels D.V.M.; Gerhard J. Mueller; Graham M. Watson M.D.; Reza S. Malek M.D.; Lawrence S. Bass M.D.; Lloyd P. Tate V.D.M.; Hans-Dieter Reidenbach; Kenneth Eugene Bartels D.V.M.; R. Rox Anderson M.D.; Lawrence S. Bass M.D.; Aaron P. Perlmutter M.D.; Kenton W. Gregory M.D.; David M. Harris; David M. Harris; Harvey Lui M.D.; Reza S. Malek M.D.; Gerhard J. Mueller; Michail M. Pankratov; Aaron P. Perlmutter M.D.; Hans-Dieter Reidenbach; Lloyd P. Tate V.D.M.; Graham M. Watson M.D., Editor(s)

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