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Proceedings Paper

In-vivo diagnostic with optical coherence tomography: use in dermatology
Author(s): Julia Welzel; Eva Lankenau; Reginald Birngruber; Ralf Engelhardt
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Paper Abstract

Optical low coherence tomography (OCT) is a newly developed bioengineering method for noninvasive in-vivo investigation of human skin, especially of the epidermis. Based on the principle of a Michelson interferometer, OCT allows the detection of the path length of an infrared light beam after backscattered inside the skin sample by comparison with a reference beam. The depth resolution is limited by the coherence length of the light source, which is about 15 micrometer. OCT supplies cross-sectional images of the skin with a penetration depth of about 0.5 to 1.5 mm. The stratum corneum can be distinguished from the living epidermis and the upper dermis. We investigated healthy skin of several localizations, inflammatory diseases, intra- and subepidermal blisters and epidermal tumors. First images are presented to demonstrate the possibilities of this promising new method.

Paper Details

Date Published: 22 May 1997
PDF: 6 pages
Proc. SPIE 2970, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VII, (22 May 1997); doi: 10.1117/12.275058
Show Author Affiliations
Julia Welzel, Medical Univ. Leubeck (Germany)
Eva Lankenau, Medical Laser Ctr. Luebeck (Germany)
Reginald Birngruber, Medical Laser Ctr. Luebeck (Germany)
Ralf Engelhardt, Medical Laser Ctr. Luebeck (Germany)


Published in SPIE Proceedings Vol. 2970:
Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VII
R. Rox Anderson; Harvey Lui; Michail M. Pankratov; Kenneth Eugene Bartels; Gerhard J. Mueller; Graham M. Watson; Reza S. Malek; Lawrence S. Bass; Lloyd P. Tate; Hans-Dieter Reidenbach; Kenneth Eugene Bartels; R. Rox Anderson; Lawrence S. Bass; Aaron P. Perlmutter; Kenton W. Gregory; David M. Harris; David M. Harris; Harvey Lui; Reza S. Malek; Gerhard J. Mueller; Michail M. Pankratov; Aaron P. Perlmutter; Hans-Dieter Reidenbach; Lloyd P. Tate; Graham M. Watson, Editor(s)

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