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Proceedings Paper

Influence of hepatic perfusion and application mode in an animal experimental study on laser-induced thermotherapy (LITT) in the liver
Author(s): Dirk Albrecht; Christoph-Thomas Germer; Christoph Martin Isbert; Andre Roggan; Heinz-Johannes Buhr
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Paper Abstract

The aim of the present animal experimental study was to investigate the effect of temporarily interrupting hepatic perfusion as well as the application mode on inducible coagulation volumes. Experiments were carried out using a Nd:YAG-laser at a wavelength of 1064 nm. A special multifiber optical component was used. Ten German hybrid pigs served as the experimental animals. All animals were sacrificed four hours after the end of application, and the livers were removed for histological examination. With a single application, a mean lesion volume of 2503 mm3 resulted from a total applied energy of 4356 J. Under temporary occlusion of hepatic circulation a lesion volume of 7452 mm3 was found (p less than 0.01). Multifiber laser application with hepatic circulation led to a mean volume of 14612 mm3. During interrupted circulation, overlapping tissue lesions with a mean volume of 50285 mm3 were induced (p less than 0.01). Microscopic examination showed that the rim seen macroscopically was identical. As well the application mode as the hepatic circulation are statistically significant parameters for the inducible lesion volumes. The interruption of the liver perfusion during laser application led to a significant increase of the hyperthermically induced tissue lesion for single- and multifiber applications.

Paper Details

Date Published: 22 May 1997
PDF: 6 pages
Proc. SPIE 2970, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VII, (22 May 1997); doi: 10.1117/12.275018
Show Author Affiliations
Dirk Albrecht, Benjamin Franklin Medical Ctr./Freie Univ. Berlin (Germany)
Christoph-Thomas Germer, Benjamin Franklin Medical Ctr./Freie Univ. Berlin (Germany)
Christoph Martin Isbert, Benjamin Franklin Medical Ctr./Freie Univ. Berlin (Germany)
Andre Roggan, Benjamin Franklin Medical Ctr./Freie Univ. Berlin (Germany)
Heinz-Johannes Buhr, Benjamin Franklin Medical Ctr./Freie Univ. Berlin (Germany)


Published in SPIE Proceedings Vol. 2970:
Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VII
R. Rox Anderson; Harvey Lui; Michail M. Pankratov; Kenneth Eugene Bartels; Gerhard J. Mueller; Graham M. Watson; Reza S. Malek; Lawrence S. Bass; Lloyd P. Tate; Hans-Dieter Reidenbach; Kenneth Eugene Bartels; R. Rox Anderson; Lawrence S. Bass; Aaron P. Perlmutter; Kenton W. Gregory; David M. Harris; David M. Harris; Harvey Lui; Reza S. Malek; Gerhard J. Mueller; Michail M. Pankratov; Aaron P. Perlmutter; Hans-Dieter Reidenbach; Lloyd P. Tate; Graham M. Watson, Editor(s)

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