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Proceedings Paper

Analysis of individual lipoproteins and liposomes
Author(s): David L. Robbins; John P. Nolan; James H. Jett; Richard A. Keller; Larry A. Sklar
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Paper Abstract

We describe the application of single molecule detection (SMD) technologies for the analysis of natural and synthetic transport systems. The need for advanced analytical procedures of these complex and important systems is presented with the specific enhancements afforded by SMD with flowing sample streams. In contrast to bulk measurements which yield only average values, measurement of individual species allows creation of population histograms form heterogeneous samples. The data are acquired in minutes and the analysis requires relatively small sample quantities. Preliminary data are presented from the analysis of low density lipoprotein, and multilamellar and unilamellar vesicles.

Paper Details

Date Published: 22 May 1997
PDF: 10 pages
Proc. SPIE 2985, Ultrasensitive Biochemical Diagnostics II, (22 May 1997); doi: 10.1117/12.274353
Show Author Affiliations
David L. Robbins, Los Alamos National Lab. (United States)
John P. Nolan, Los Alamos National Lab. (United States)
James H. Jett, Los Alamos National Lab. (United States)
Richard A. Keller, Los Alamos National Lab. (United States)
Larry A. Sklar, Univ. of New Mexico School of Medicine (United States)


Published in SPIE Proceedings Vol. 2985:
Ultrasensitive Biochemical Diagnostics II
Gerald E. Cohn; Gerald E. Cohn; Steven A. Soper, Editor(s)

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