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Proceedings Paper

Optical Doppler tomography for noninvasive imaging of in-vivo blood flow
Author(s): Zhongping Chen; Thomas E. Milner; Shyam M. Srinivas; Tore Lindmo; Digant P. Dave; J. Stuart Nelson
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Paper Abstract

We report the development of an optical technique for noninvasive in vivo imaging of tissue structure and blood flow dynamics with high spatial resolution (2 - 15 micrometer) in biological systems. The technique is based on coherence optical Doppler tomography (ODT), which combines Doppler velocimetry with optical coherence tomography to measure blood flow velocity at discrete spatial locations. The exceptionally high resolution of ODT allows noninvasive in vivo imaging of both blood microcirculation and tissue structures surrounding the vessel, which has significance for biomedical research and clinical applications. Tomographic velocity imaging of in vivo blood flow in a rat mesentery is demonstrated.

Paper Details

Date Published: 22 May 1997
PDF: 7 pages
Proc. SPIE 2981, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications, (22 May 1997); doi: 10.1117/12.274308
Show Author Affiliations
Zhongping Chen, Beckman Laser Institute and Medical Clinic (United States)
Thomas E. Milner, Beckman Laser Institute and Medical Clinic (United States)
Shyam M. Srinivas, Beckman Laser Institute and Medical Clinic (United States)
Tore Lindmo, Norwegian Univ. of Science and Technology (Norway)
Digant P. Dave, Beckman Laser Institute and Medical Clinic (United States)
J. Stuart Nelson, Beckman Laser Institute and Medical Clinic (United States)


Published in SPIE Proceedings Vol. 2981:
Coherence Domain Optical Methods in Biomedical Science and Clinical Applications
Valery V. Tuchin; Halina Podbielska; Ben Ovryn, Editor(s)

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