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Proceedings Paper

Development and validation of technique for in-vivo 3D analysis of cranial bone graft survival
Author(s): Mark P. Bernstein; Curtis B. Caldwell; Oleh M. Antonyshyn; Karen Ma; Perry W. Cooper; Lisa E. Ehrlich
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Paper Abstract

Bone autografts are routinely employed in the reconstruction of facial deformities resulting from trauma, tumor ablation or congenital malformations. The combined use of post- operative 3D CT and SPECT imaging provides a means for quantitative in vivo evaluation of bone graft volume and osteoblastic activity. The specific objectives of this study were: (1) Determine the reliability and accuracy of interactive computer-assisted analysis of bone graft volumes based on 3D CT scans; (2) Determine the error in CT/SPECT multimodality image registration; (3) Determine the error in SPECT/SPECT image registration; and (4) Determine the reliability and accuracy of CT-guided SPECT uptake measurements in cranial bone grafts. Five human cadaver heads served as anthropomorphic models for all experiments. Four cranial defects were created in each specimen with inlay and onlay split skull bone grafts and reconstructed to skull and malar recipient sites. To acquire all images, each specimen was CT scanned and coated with Technetium doped paint. For purposes of validation, skulls were landmarked with 1/16-inch ball-bearings and Indium. This study provides a new technique relating anatomy and physiology for the analysis of cranial bone graft survival.

Paper Details

Date Published: 9 May 1997
PDF: 9 pages
Proc. SPIE 3033, Medical Imaging 1997: Physiology and Function from Multidimensional Images, (9 May 1997); doi: 10.1117/12.274072
Show Author Affiliations
Mark P. Bernstein, Sunnybrook Health Science Ctr./Univ. of Toronto (Canada)
Curtis B. Caldwell, Sunnybrook Health Science Ctr./Univ. of Toronto (Canada)
Oleh M. Antonyshyn, Sunnybrook Health Science Ctr./Univ. of Toronto (Canada)
Karen Ma, Sunnybrook Health Science Ctr./Univ. of Toronto (Canada)
Perry W. Cooper, Sunnybrook Health Science Ctr./Univ. of Toronto (Canada)
Lisa E. Ehrlich, Sunnybrook Health Science Ctr./Univ. of Toronto (Canada)


Published in SPIE Proceedings Vol. 3033:
Medical Imaging 1997: Physiology and Function from Multidimensional Images
Eric A. Hoffman, Editor(s)

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