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Proceedings Paper

Effect of photodynamic therapy in intimal hyperplasia by phthalocyanine conjugated to the scavenger-receptor ligand, maleylated bovine serum albumin
Author(s): Shigeki Ito; Tsuneyuki Nagae; Shin Ishimaru; Sara Chau; Triet Dang; Leslie Anne Sabiniano; Mizuho Zempo; Mark C. Booth; Lih-Huei L. Liaw; Tatiana B. Krasieva; Bruce J. Tromberg; Johan E. van Lier; Michael W. Berns; Samuel E. Wilson
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Paper Abstract

Initial hyperplasia is major cause of restenosis after vascular interventions for arterial occlusive disease. We reported that a fluorescent probe, Texas Red, conjugated to the scavenger-receptor ligand, maleylated bovine serum albumin accumulated almost exclusively in the injured, hyperplastic sites. The purpose of this study is to test the feasibility of enhanced drug delivery to the hyperplastic lesion by targeting the scavenger-receptors.

Paper Details

Date Published: 9 May 1997
PDF: 17 pages
Proc. SPIE 3033, Medical Imaging 1997: Physiology and Function from Multidimensional Images, (9 May 1997); doi: 10.1117/12.274054
Show Author Affiliations
Shigeki Ito, Tokyo Medical College (Japan)
Tsuneyuki Nagae, Tokyo Medical College (Japan)
Shin Ishimaru, Tokyo Medical College (Japan)
Sara Chau, Beckman Laser Institute and Medical Clinic (United States)
Triet Dang, Beckman Laser Institute and Medical Clinic (United States)
Leslie Anne Sabiniano, Beckman Laser Institute and Medical Clinic (United States)
Mizuho Zempo, Beckman Laser Institute and Medical Clinic (United States)
Mark C. Booth, Beckman Laser Institute and Medical Clinic (United States)
Lih-Huei L. Liaw, Beckman Laser Institute and Medical Clinic (United States)
Tatiana B. Krasieva, Beckman Laser Institute and Medical Clinic (United States)
Bruce J. Tromberg, Beckman Laser Institute and Medical Clinic (United States)
Johan E. van Lier, Univ. of Sherbrooke (Canada)
Michael W. Berns, Beckman Laser Institute and Medical Clinic (United States)
Samuel E. Wilson, Beckman Laser Institute and Medical Clinic (United States)


Published in SPIE Proceedings Vol. 3033:
Medical Imaging 1997: Physiology and Function from Multidimensional Images
Eric A. Hoffman, Editor(s)

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