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Proceedings Paper

Definition of preclinical and clinical character of human symptomatic status by quasi-elastic light scattering (QELS) investigations of blood plasma
Author(s): Mariya A. Ivanova; Nicolay V. Klopov; Andrei D. Lebedev; Leonid A. Noskin; Valentin A. Noskin; Michail Yu. Pavlov
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Paper Abstract

We discuss the use of the QELS method for screening of population groups for verified pathologies. For mathematical analysis of experimental data the regularization procedure have been used. This allows us to determine the histograms of particle size distribution of blood plasma samples. For the interpretation of the histogram data the special program of the mathematical processing - 'semiotic classifier' - have been created. The main idea of the 'semiotic classifier' is based on the fact, that formation of the pathological trace in human organism depends not only on concrete disease nature but also on the interaction between the organism sanogenetic mechanisms. We separate five pathological symptomatic complexes of organism status: allergic diseases, intoxications, organism catabolic shifts, auto-immune diseases and degenerative-dystrophy processes. The use of this 'semiotic classifier' in the system of monitoring investigations allows to solve the next problems: (1) to separate the persons with the expressed initial level of pathological processes to the risk groups for the special clinical investigations, (2) to set up the predisposition of the concrete individual towards definite pathologies at the preclinical stage, (3) under the conditions of expressed clinical pathology to study the dynamics of pathology processes.

Paper Details

Date Published: 2 May 1997
PDF: 8 pages
Proc. SPIE 2982, Optical Diagnostics of Biological Fluids and Advanced Techniques in Analytical Cytology, (2 May 1997); doi: 10.1117/12.273631
Show Author Affiliations
Mariya A. Ivanova, St. Petersburg Institute of Nuclear Physics (Russia)
Nicolay V. Klopov, St. Petersburg Institute of Nuclear Physics (Russia)
Andrei D. Lebedev, St. Petersburg Institute of Nuclear Physics (Russia)
Leonid A. Noskin, St. Petersburg Institute of Nuclear Physics (Russia)
Valentin A. Noskin, Institute of New Technologies in Education (Russia)
Michail Yu. Pavlov, Institute of Hygiene and Occupational Pathology (Russia)

Published in SPIE Proceedings Vol. 2982:
Optical Diagnostics of Biological Fluids and Advanced Techniques in Analytical Cytology
Robert C. Leif; Alexander V. Priezzhev; Toshimitsu Asakura; Robert C. Leif, Editor(s)

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