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Proceedings Paper

LDF assessment of tumor blood flow and flux motions in photodynamic therapy
Author(s): Valentine I. Kozlov; Oleg Alexandrov Terman
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Paper Abstract

In patients with basal cell carcinoma (BCC) skin microcirculation was measured by the laser Doppler flowmeter (LDF). Spectral analysis of LDF-signal based on fast Fourier transform enables us to evaluate an amplitude and predominated frequency of flux motions in the next diapasons: (alpha) -rhythm, (beta) -rhythm, (gamma) -rhythm, high-frequency rhythm and cardiorhythm. For photodynamic therapy (PDT) hematoporphyrin derivative was administrated intravenously in dosage 1-2 mg/Kg. In 24 hours after that all patients were exposed to the red laser irradiation in dose 200-300 J/cm2. The microcirculation level in BCC was higher than in the plots of healthy skin. Exactly after PDT the marked decrease of microcirculation up to 4.7 +/- 0.63 a.u. associated with photoinduced stasis took place in the tumor. Spectral analysis of flux motions demonstrated a significant inhibition of (alpha) -, (beta) -rhythms and amplification of HF- and CF-rhythm In 1 week after PDT we observed a gradual restoration of microcirculation in the zone of PDT skin injury that followed a wound healing process.

Paper Details

Date Published: 2 May 1997
PDF: 7 pages
Proc. SPIE 2982, Optical Diagnostics of Biological Fluids and Advanced Techniques in Analytical Cytology, (2 May 1997); doi: 10.1117/12.273612
Show Author Affiliations
Valentine I. Kozlov, Russian Univ. of Peoples' Friendship (Russia)
Oleg Alexandrov Terman, State Research Ctr. for Laser Medicine (Russia)


Published in SPIE Proceedings Vol. 2982:
Optical Diagnostics of Biological Fluids and Advanced Techniques in Analytical Cytology
Robert C. Leif; Alexander V. Priezzhev; Toshimitsu Asakura; Robert C. Leif, Editor(s)

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