Share Email Print

Proceedings Paper

LDF assessment of tumor blood flow and flux motions in photodynamic therapy
Author(s): Valentine I. Kozlov; Oleg Alexandrov Terman
Format Member Price Non-Member Price
PDF $14.40 $18.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

In patients with basal cell carcinoma (BCC) skin microcirculation was measured by the laser Doppler flowmeter (LDF). Spectral analysis of LDF-signal based on fast Fourier transform enables us to evaluate an amplitude and predominated frequency of flux motions in the next diapasons: (alpha) -rhythm, (beta) -rhythm, (gamma) -rhythm, high-frequency rhythm and cardiorhythm. For photodynamic therapy (PDT) hematoporphyrin derivative was administrated intravenously in dosage 1-2 mg/Kg. In 24 hours after that all patients were exposed to the red laser irradiation in dose 200-300 J/cm2. The microcirculation level in BCC was higher than in the plots of healthy skin. Exactly after PDT the marked decrease of microcirculation up to 4.7 +/- 0.63 a.u. associated with photoinduced stasis took place in the tumor. Spectral analysis of flux motions demonstrated a significant inhibition of (alpha) -, (beta) -rhythms and amplification of HF- and CF-rhythm In 1 week after PDT we observed a gradual restoration of microcirculation in the zone of PDT skin injury that followed a wound healing process.

Paper Details

Date Published: 2 May 1997
PDF: 7 pages
Proc. SPIE 2982, Optical Diagnostics of Biological Fluids and Advanced Techniques in Analytical Cytology, (2 May 1997); doi: 10.1117/12.273612
Show Author Affiliations
Valentine I. Kozlov, Russian Univ. of Peoples' Friendship (Russia)
Oleg Alexandrov Terman, State Research Ctr. for Laser Medicine (Russia)

Published in SPIE Proceedings Vol. 2982:
Optical Diagnostics of Biological Fluids and Advanced Techniques in Analytical Cytology
Robert C. Leif; Alexander V. Priezzhev; Toshimitsu Asakura; Robert C. Leif, Editor(s)

© SPIE. Terms of Use
Back to Top