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Proceedings Paper

Fluorescence probe for cervical examination during various reproductive states
Author(s): Wenling S. Glassman; Qin-Ping Liao; Shao-Qing Shi; Linda Goodrum; Gayle Olson; Elizabeth Martin; George Saade; Robert E. Garfield
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Paper Abstract

These studies represent further investigations that have been done utilizing the fluorescence from pyridinoline, one of the major crosslinks of type I and III collagen, to evaluate cervical connective tissue changes during various female reproductive periods. Based on our previous studies, a prototype instrument has been constructed. The instrument was specifically designed for the purpose of vaginal examination of cervical connective tissue by measuring light induced fluorescence directly from the surface of the external os of the cervix. The studies were carried out on nonpregnant rats, rats during gestation at different periods, rats at different times during postpartum, and rats during preterm birth after being treated with antiprogesterone drugs. A study has also been done on humans during pregnancy and postpartum. The results parallel previous investigations that have used various invasive methods to analyze cervical extensibility, cervical collagen content and collagenase. In consideration of the important role of the collagen fibers and their turnover in the process of cervical function during pregnancy (softening or ripening at term), this method could be a useful tool for evaluating treatment strategies of the cervix. Moreover, the instrument could serve as a device for the non-invasive estimation of cervical status in the clinic and the diagnosis of the changes in the cervix during the preparation for labor.

Paper Details

Date Published: 7 May 1997
PDF: 7 pages
Proc. SPIE 2980, Advances in Fluorescence Sensing Technology III, (7 May 1997); doi: 10.1117/12.273513
Show Author Affiliations
Wenling S. Glassman, Univ. of Texas Medical Branch at Galveston (United States)
Qin-Ping Liao, Univ. of Texas Medical Branch at Galveston (United States)
Shao-Qing Shi, Univ. of Texas Medical Branch at Galveston (United States)
Linda Goodrum, Univ. of Texas Medical Branch at Galveston (United States)
Gayle Olson, Univ. of Texas Medical Branch at Galveston (United States)
Elizabeth Martin, Univ. of Texas Medical Branch at Galveston (United States)
George Saade, Univ. of Texas Medical Branch at Galveston (United States)
Robert E. Garfield, Univ. of Texas Medical Branch at Galveston (United States)


Published in SPIE Proceedings Vol. 2980:
Advances in Fluorescence Sensing Technology III
Richard B. Thompson, Editor(s)

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