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Proceedings Paper

Measurement of the triplet-state yield of photosensitizers in scattering media
Author(s): Brian W. Pogue; Lothar D. Lilge; Kai Zhang; Brian C. Wilson; Robert W. Redmond; Tayyaba Hasan
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Paper Abstract

A methodology is presented which enables quantification of the fraction of photosensitizer which is photo-converted to the triplet state within homogeneously scattering media. The method relies on a correlation of absorbance with diffuse reflectance changes measured in samples of photosensitizer in scattering medium and can estimate the fraction of photosensitizer molecules present in the active monomeric form. The validity of this approach is demonstrated for the sensitizer tin etioporphyrin in a model system of lipid in water emulsion and is expected to be applicable to biological systems such as cell suspensions and tissue.

Paper Details

Date Published: 8 May 1997
PDF: 5 pages
Proc. SPIE 2972, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy VI, (8 May 1997); doi: 10.1117/12.273502
Show Author Affiliations
Brian W. Pogue, Massachusetts General Hospital/Harvard Medical School (United States)
Lothar D. Lilge, Univ. of Toronto (Canada)
Kai Zhang, Univ. of Toronto (Canada)
Brian C. Wilson, Univ. of Toronto (Canada)
Robert W. Redmond, Massachusetts General Hospital/Harvard Medical School (United States)
Tayyaba Hasan, Massachusetts General Hospital/Harvard Medical School (United States)


Published in SPIE Proceedings Vol. 2972:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy VI
Thomas J. Dougherty, Editor(s)

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