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Proceedings Paper

S-layers as patterning structures and supporting layers for biomimetic membranes
Author(s): Dietmar Pum; Barbara Wetzer; Bernhard Schuster; Uwe B. Sleytr
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Paper Abstract

A new approach in nanostructure technology particularly in the functionalization of surfaces has been developed on the basis of crystalline bacterial cell surface layers (S- layers). S-layers are composed of monomolecular arrays of identical (glyco)proteins showing high molecular order, defined mass distribution and isoporosity, and a high binding capacity for functional macromolecules. The possibility for recrystallizing isolated S-layer subunits into large isoporous, coherent lattices at solid supports, at the air/water interface or on lipid films and for handling such layers by standard Langmuir-Blodgett techniques opens a broad spectrum of applications in basic and applied membrane research. S-layer supported functional phospholipid bilayers or tetraether lipid films mimic the molecular architecture of those archaebacterial cell envelopes that are exclusively composed of an S-layer and a plasma membrane. This novel concept could lead to new techniques for exploiting large scale structural and functional principles of membrane associated and integrated molecules (e.g. ion channels, proton pumps, receptors).

Paper Details

Date Published: 31 March 1997
PDF: 5 pages
Proc. SPIE 2978, Micro- and Nanofabricated Electro-Optical Mechanical Systems for Biomedical and Environmental Applications, (31 March 1997); doi: 10.1117/12.269979
Show Author Affiliations
Dietmar Pum, Univ. fuer Bodenkultur (Austria)
Barbara Wetzer, Univ. fuer Bodenkultur (Austria)
Bernhard Schuster, Univ. fuer Bodenkultur (Austria)
Uwe B. Sleytr, Univ. fuer Bodenkultur (Austria)

Published in SPIE Proceedings Vol. 2978:
Micro- and Nanofabricated Electro-Optical Mechanical Systems for Biomedical and Environmental Applications
Paul Lee Gourley, Editor(s)

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