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Proceedings Paper

Boron neutron capture (BNC): a mechanism for enhancing tumor cell kill in fast neutron radiotherapy
Author(s): George E. Laramore; T. W. Griffin; R. Risler; P. Wootton; K. J. Stelzer; D. S. Wilbur
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Paper Abstract

At therapeutic doses fast neutron radiotherapy alone gives significant tumor control can result in a significant increase in tumor control probability. As a fast neutron beam penetrates tissue it is partially moderated producing a cloud of thermalized neutrons. We describe measurements of this thermalized component using the therapy beam at the University of Washington and show how it is possible to increase its magnitude without appreciable degradation of the other clinical properties of the beam. We describe model calculation of the radiobiological effects of a boron neutron capture boost as well as in vitro cell culture measurements on the V-79 cell line, in vivo experiments on the 36B10 rat glioma system, and a preliminary experiment on a human melanoma nodule test system. Plans to extend this work to clinically-relevant tumor systems are discussed.

Paper Details

Date Published: 27 February 1997
PDF: 4 pages
Proc. SPIE 2867, International Conference Neutrons in Research and Industry, (27 February 1997); doi: 10.1117/12.267889
Show Author Affiliations
George E. Laramore, Univ. of Washington Medical Ctr. (United States)
T. W. Griffin, Univ. of Washington Medical Ctr. (United States)
R. Risler, Univ. of Washington Medical Ctr. (United States)
P. Wootton, Univ. of Washington Medical Ctr. (United States)
K. J. Stelzer, Univ. of Washington Medical Ctr. (United States)
D. S. Wilbur, Univ. of Washington Medical Ctr. (United States)


Published in SPIE Proceedings Vol. 2867:
International Conference Neutrons in Research and Industry

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