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Proceedings Paper

Research in boron neutron capture synovectomy
Author(s): E. Binello; S. Shortkroff; A. Jones; C. Viveiros; A. Ly; C. B. Sledge; A. Davison; Ruth E. Shefer; Jacquelyn C. Yanch
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Paper Abstract

Boron Neutron Capture Synovectomy (BNCS) is a novel application of the 10B(n, (alpha) )7Li reaction for the treatment of Rheumatoid Arthritis. This potential treatment modality is in its developmental stages; in this paper results of research in two aspects of BNCS are presented. First, quantification of 10B-uptake in samples of human arthritic tissue by Prompt Gamma Neutron Activation Analysis is presented. 10B concentrations from 1625 to 2726 ppm are readily achieved. Second, ideal neutron beam studies have been undertaken and indicate that neutrons from thermal energies to 1 keV are useful for BNCS. This information is of use in designing practical therapy beams should this treatment modality be realized.

Paper Details

Date Published: 27 February 1997
PDF: 4 pages
Proc. SPIE 2867, International Conference Neutrons in Research and Industry, (27 February 1997); doi: 10.1117/12.267854
Show Author Affiliations
E. Binello, Massachusetts Institute of Technology (United States)
S. Shortkroff, Brigham and Women's Hospital (United States)
A. Jones, Brigham and Women's Hospital (United States)
C. Viveiros, Brigham and Women's Hospital (United States)
A. Ly, Massachusetts Institute of Technology (United States)
C. B. Sledge, Brigham and Women's Hospital (United States)
A. Davison, Massachusetts Institute of Technology (United States)
Ruth E. Shefer, Newton Scientific Inc. (United States)
Jacquelyn C. Yanch, Massachusetts Institute of Technology (United States)


Published in SPIE Proceedings Vol. 2867:
International Conference Neutrons in Research and Industry
George Vourvopoulos, Editor(s)

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