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Proceedings Paper

Molecular recognition and optical detection of biological pathogens at biomimetic membrane interfaces
Author(s): John J. Pan; Deborah H. Charych
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Paper Abstract

Molecular recognition sites on cell membranes serve as the main communication channels between the inside of a cell and its surroundings. Upon receptor binding, cellular messages such as ion channel opening or activation of enzymes are triggered. In this report, we demonstrate that artificial cell membranes made from conjugated lipid polymers (polydiacetylene) can, on a simple level, mimic membrane processes of molecular recognition and signal transduction. The ganglioside, GMI was incorporated into polydiacetylene liposomes. Molecular recognition of cholera toxin at the interface of the liposome resulted in a change of the membrane color due to conformational changes in the conjugated (ene-yne) polymer backbone. The `colored liposomes' might be used as simple colorimetric sensors for drug screening or as new tools to study membrane-membrane or membrane-receptor interactions.

Paper Details

Date Published: 14 February 1997
PDF: 7 pages
Proc. SPIE 3040, Smart Structures and Materials 1997: Smart Materials Technologies, (14 February 1997); doi: 10.1117/12.267115
Show Author Affiliations
John J. Pan, Lawrence Berkeley National Lab. (United States)
Deborah H. Charych, Lawrence Berkeley National Lab. (United States)

Published in SPIE Proceedings Vol. 3040:
Smart Structures and Materials 1997: Smart Materials Technologies
Wilbur C. Simmons; Ilhan A. Aksay; Dryver R. Huston, Editor(s)

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