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Proceedings Paper

Analysis of drugs in human tissues by supercritical fluid extraction/immunoassay
Author(s): Kenneth G. Furton; Alberta Sabucedo; Joseph Rein; W. Lee Hearn
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Paper Abstract

A rapid, readily automated method has been developed for the quantitative analysis of phenobarbital from human liver tissues based on supercritical carbon dioxide extraction followed by fluorescence enzyme immunoassay. The method developed significantly reduces sample handling and utilizes the entire liver homogenate. The current method yields comparable recoveries and precision and does not require the use of an internal standard, although traditional GC/MS confirmation can still be performed on sample extracts. Additionally, the proposed method uses non-toxic, inexpensive carbon dioxide, thus eliminating the use of halogenated organic solvents.

Paper Details

Date Published: 10 February 1997
PDF: 5 pages
Proc. SPIE 2941, Forensic Evidence Analysis and Crime Scene Investigation, (10 February 1997); doi: 10.1117/12.266308
Show Author Affiliations
Kenneth G. Furton, Florida International Univ. (United States)
Alberta Sabucedo, Florida International Univ. (United States)
Joseph Rein, Dade County Medical Examiner's Office (United States)
W. Lee Hearn, Dade County Medical Examiner's Office (United States)

Published in SPIE Proceedings Vol. 2941:
Forensic Evidence Analysis and Crime Scene Investigation
John Hicks; Peter R. De Forest; Vivian M. Baylor, Editor(s)

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