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Proceedings Paper

Mathematical modeling of cell proliferation dynamics in psoriatic epidermis sensitized by the furocoumarins under UVA radiation
Author(s): Pavel V. Baskakov; Mikhail M. Stolnitz
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Paper Abstract

In the work the mathematical model is presented which describes the processes in the epidermis sensitized by the furocoumarins under UVA-radiation. The model describes the processes at three levels: molecular (the photochemical transformations of the psoralen molecules and their reactions with the DNA-molecules), cellular (proliferation, differentiation and repairing of injuries), and tissue (humoral regulation, space-time cell dynamics in the epidermis). The results of the numerical simulations of both the latent period and psoriasis manifestation are given. The therapeutical effect of the UV-radiation is considered in the framework of the model.

Paper Details

Date Published: 11 February 1997
PDF: 18 pages
Proc. SPIE 3053, Nonlinear Dynamics and Structures in Biology and Medicine: Optical and Laser Technologies: International Workshop, (11 February 1997); doi: 10.1117/12.266242
Show Author Affiliations
Pavel V. Baskakov, Saratov State Univ. (Russia)
Mikhail M. Stolnitz, Saratov State Univ. (Russia)


Published in SPIE Proceedings Vol. 3053:
Nonlinear Dynamics and Structures in Biology and Medicine: Optical and Laser Technologies: International Workshop
Valery V. Tuchin, Editor(s)

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