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Proceedings Paper

Laser-induced fluorescence as a diagnostic tool in atherosclerosis
Author(s): Nikoletta Anastasopoulou; B. Arapoglou; P. Demakakos; Mersini I. Makropoulou; A. Paphiti; Y. S. Raptis; Alexander A. Serafetinides
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Paper Abstract

Experiments on atherosclerotic plaque diagnosis were carried out using laser induced fluorescence. Different excitation wavelengths were tested: 488 nm and 457.9 nm of a c.w. Ar+ laser as well as 476 nm and 407 nm of a c.w. Kr+ laser. Over 15 samples were examined and several spectra were obtained from each sample. Results were cross- examined with conventional clinical techniques, such as histopathological diagnosis, which showed three main components of the atherosclerotic plaque: fibrous tissue, lipid constituents and calcified plaque. An effort was made to distinguish the composition of the sample from the obtained spectra. Fluorescence spectra corresponding to calcified plaque present their maximum in the area of 530 nm - 550 nm. However, there was not observed a specific wavelength where spectra corresponding to fibrous tissue and lipid constituents present maximum. Full width half maximum of the fluorescence spectra was also measured and the ratio of the fluorescence intensity at 600 nm over the intensity at 576 nm, I(600)/I(576), was calculated.

Paper Details

Date Published: 27 December 1996
PDF: 6 pages
Proc. SPIE 3052, Ninth International School on Quantum Electronics: Lasers--Physics and Applications, (27 December 1996); doi: 10.1117/12.262964
Show Author Affiliations
Nikoletta Anastasopoulou, National Technical Univ. of Athens (Greece)
B. Arapoglou, Univ. of Athens (Greece)
P. Demakakos, Univ. of Athens (Greece)
Mersini I. Makropoulou, National Technical Univ. of Athens (Greece)
A. Paphiti, Univ. of Athens (Greece)
Y. S. Raptis, National Technical Univ. of Athens (Greece)
Alexander A. Serafetinides, National Technical Univ. of Athens (Greece)

Published in SPIE Proceedings Vol. 3052:
Ninth International School on Quantum Electronics: Lasers--Physics and Applications
Peter A. Atanasov, Editor(s)

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