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Proceedings Paper

First experience of application of photodynamic therapy in keratoplasty
Author(s): Svyatoslav N. Fyodorov; V. G. Kopayeva; Yu. V. Andreev; Eugeny Ph. Stranadko; G. V. Ponomariov
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Paper Abstract

Vascular effect of photodynamic therapy has been studied in patients with corneal neovascularized transplant in 10 cases. THe injection of photoheme intravenously were made with subsequent irradiation by light of argon-pumped dye laser with light density of 150-300 mW/cm2 for 10-15 minutes. Energy density consisted 150-300 J/cm2. In all the cases at the time of irradiation the aggregated blood flow was appeared followed by blood flow stasis. In post- operative period the vessels disintegrated into separate fragments which disappeared completely after 10-15 days. Taking into account the data of light microscope, the disappearance of the vessels took place as a result of the vascular endothelium lysis along the vascular walls. The vessel alteration study presented in this paper, may also serve to specify the mechanism of photodynamic destruction of neovascularized stroma of tumor.

Paper Details

Date Published: 5 December 1996
PDF: 3 pages
Proc. SPIE 2930, Lasers in Ophthalmology IV, (5 December 1996); doi: 10.1117/12.260884
Show Author Affiliations
Svyatoslav N. Fyodorov, State Research Ctr. for Laser Medicine (Russia)
V. G. Kopayeva, State Research Ctr. for Laser Medicine (Russia)
Yu. V. Andreev, State Research Ctr. for Laser Medicine (Russia)
Eugeny Ph. Stranadko, State Research Ctr. for Laser Medicine (Russia)
G. V. Ponomariov, State Research Ctr. for Laser Medicine (Russia)


Published in SPIE Proceedings Vol. 2930:
Lasers in Ophthalmology IV
Reginald Birngruber; Adolf Friedrich Fercher; Philippe Sourdille, Editor(s)

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