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Proceedings Paper

Quantification of hemoglobin saturation on tissue phantom using phase-modulation spectroscopy
Author(s): Congwu Du; Hanli Liu; Britton Chance
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Paper Abstract

Int his article, we analytically present the influence of the systematic error due to the theoretical assumptions on the blood oxygenation determination using a 'phase-only' dual-wavelength phase-modulation spectroscopy (PMS). To approach an accurate quantification of hemoglobin saturation, an empirical method to experimentally acquire the initial phase-shift value in oxygenation quantification form PMS data is investigated on blood-perfused phantom. Our results show that the quantification error of blood oxygenation determination can be substantially compensated by using the acquired (theta) 0(lambda ) method and is confirmed to be less than 10 percent by comparison with the measured results of the Pt electrode.

Paper Details

Date Published: 6 December 1996
PDF: 10 pages
Proc. SPIE 2925, Photon Propagation in Tissues II, (6 December 1996); doi: 10.1117/12.260836
Show Author Affiliations
Congwu Du, Univ. of Pennsylvania (United States)
Hanli Liu, Univ. of Pennsylvania (United States)
Britton Chance, Univ. of Pennsylvania (United States)


Published in SPIE Proceedings Vol. 2925:
Photon Propagation in Tissues II
David A. Benaron M.D.; Britton Chance; Gerhard J. Mueller, Editor(s)

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