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Proceedings Paper

Extraction of optical tissue parameters in semi-infinite geometry using the PDW approach
Author(s): Thomas Bocher; Hans-Georg Eberle; Rolf-Dieter Naber; Olaf Minet; Juergen Beuthan; Gerhard J. Mueller
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Paper Abstract

For many different optical applications in medical diagnosis, like optical biopsy or optical tomography, it is important to know about the local varying optical tissue parameters. Only the knowledge of these parameters (mu) a, (mu) s' allows a proper interpretation of particular fluorescence or scattering intensities. THe research presented here deals with basic investigations about the extraction of optical parameters in the first cell layers from the tissue surface down to the depth of some millimeters. The paper includes results from fiberbased measurements with Intralipid20 phantoms in infinite and semi-infinite geometry and a discussion about the possibilities to develop a flying-spot scanner. This frequency domain scanning device is under construction. It can be applied within the validity range of the diffusion approximation and provides a full (mu) a and (mu) s detection possibility in a 2D, non-contract mapping mode.

Paper Details

Date Published: 6 December 1996
PDF: 11 pages
Proc. SPIE 2925, Photon Propagation in Tissues II, (6 December 1996); doi: 10.1117/12.260828
Show Author Affiliations
Thomas Bocher, Universitaetsklinikum Benjamin Franklin der Freien Univ. Berlin (Germany)
Hans-Georg Eberle, Universitaetsklinikum Benjamin Franklin der Freien Univ. Berlin (Germany)
Rolf-Dieter Naber, Laser- und Medizintechnologie gGmbH Berlin (Germany)
Olaf Minet, Universitaetsklinikum Benjamin Franklin der Freien Univ. Berlin (Germany)
Juergen Beuthan, Universitaetsklinikum Benjamin Franklin der Freien Univ. Berlin (Germany)
Gerhard J. Mueller, Universitaetsklinikum Benjamin Franklin der Freien Univ. Berlin and Laser- und Medizintec (Germany)


Published in SPIE Proceedings Vol. 2925:
Photon Propagation in Tissues II
David A. Benaron; Britton Chance; Gerhard J. Mueller, Editor(s)

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