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Proceedings Paper

Laser fluorescence investigation of chlorin e6 pharmacokinetics
Author(s): Vladimir A. Hovanessian; Asatour Lalaian; Grigor Gyulkhandanyan
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Paper Abstract

The pharmacokinetic behavior of chlorin e6 in different organs and tumor tissues of rats infected with Sarcoma-45 has been investigated with help of the fiber-optic spectrofluorometer at excitation by harmonics of YAG:Nd laser ((lambda) equals 355, 532 and 660 nm). The most intensive chlorine e6 fluorescence in tumor tissue was observed in 18 hours after pigment injection. The optimal time of fluorescence diagnosis has been determined (in 27 hours after pigment injection). The maximum of the tumor-to- normal tissue ratio of fluorescence was equal 10 at 666 nm. The rates of the accumulation and elimination of chlorin e6 in the skin, hypodermic tissues and tumors of rats were determined in vivo.

Paper Details

Date Published: 4 December 1996
PDF: 5 pages
Proc. SPIE 2924, Photochemotherapy: Photodynamic Therapy and Other Modalities II, (4 December 1996); doi: 10.1117/12.260784
Show Author Affiliations
Vladimir A. Hovanessian, Laserayin Tekhnika Research Institute (Armenia)
Asatour Lalaian, Laserayin Tekhnika Research Institute (Armenia)
Grigor Gyulkhandanyan, Institute of Biotechnology (Armenia)

Published in SPIE Proceedings Vol. 2924:
Photochemotherapy: Photodynamic Therapy and Other Modalities II
Stanley B. Brown; Benjamin Ehrenberg; Johan Moan, Editor(s)

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