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Proceedings Paper

Laser-induced fluorescence spectroscopy of AlPc4 and liposomal ZnPc in a rat bladder tumor model and correlation with PDT efficiency
Author(s): N. J. Edinak; Angelika C. Rueck; Rudolf W. Steiner; Felicitas Genze; Victor B. Loschenov
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Paper Abstract

The problem of opportune diagnostic and treatment modalities is very actual. In recent years special attention has been paid to the development of new methods for the diagnostic of tumor spreading. That allows a physician to determine the method of further therapy. The success of PDT is defined by available accumulation of the PS in tumor tissue, therefore the photosensitizer concentration control determines the efficacy of the therapy. The methods that allow accumulation of PS in the therapeutic dose allowed us to perform PDT with smaller administration dose and avoid the complications of photosensitivity. The preliminary results of using ZnPc and AlPc in the rats show that we can reduce the dose of the drug with the increasing of the efficacy of the treatment simultaneously, if we use the PS under the control of the accumulation for the best contrast between normal and tumor tissue and try to apply methods of treatment which allow us to receive more oxygenation and using the affect of more accumulation of the drug after preliminary laser stimulation.

Paper Details

Date Published: 4 December 1996
PDF: 2 pages
Proc. SPIE 2924, Photochemotherapy: Photodynamic Therapy and Other Modalities II, (4 December 1996); doi: 10.1117/12.260778
Show Author Affiliations
N. J. Edinak, Cancer Research Ctr. (Russia)
Angelika C. Rueck, Institut fuer Lasertechnologien in der Medizin und Messtechnik (Germany)
Rudolf W. Steiner, Institut fuer Lasertechnologien in der Medizin und Messtechnik/Univ. Ulm (Germany)
Felicitas Genze, Institut fuer Lasertechnologien in der Medizin und Messtechnik/Univ. Ulm (Germany)
Victor B. Loschenov, NIOPIK Institute of Organic Intermediates and Dyes (Russia)


Published in SPIE Proceedings Vol. 2924:
Photochemotherapy: Photodynamic Therapy and Other Modalities II
Stanley B. Brown; Benjamin Ehrenberg; Johan Moan, Editor(s)

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