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Proceedings Paper

Novel effective sensitizers for photodynamic cancer therapy on the base of chlorin p6 and its derivatives
Author(s): Andrei F. Mironov; Ol'ga A. Efremova; Raisa I. Yakubovskaya; Natalia I. Kazachkina; Galina I. Fomina; Larisa A. Shitova; Natalia N. Zharkova
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Paper Abstract

A series of chlorin p6 derivatives modified at the 3- position of the macrocycle were prepared on the base of purpurin 18. The chlorins obtained have intense absorption maxima in the range of 665 - 698 nm and posses good water- solubility. Studying photodynamic activity of these sensitizers in vitro showed that the most effective was 3- devinyl-3-formylchlorin p6. This sensitizer demonstrated also enhanced in vivo affinity to the tumor tissue in comparison to other chlorins, which correlated with the pH values of aqueous solutions of sensitizers studied.

Paper Details

Date Published: 4 December 1996
PDF: 7 pages
Proc. SPIE 2924, Photochemotherapy: Photodynamic Therapy and Other Modalities II, (4 December 1996); doi: 10.1117/12.260774
Show Author Affiliations
Andrei F. Mironov, Lomonsov State Academy of Fine Chemical Technology (Russia)
Ol'ga A. Efremova, Lomonsov State Academy of Fine Chemical Technology (Russia)
Raisa I. Yakubovskaya, P.A. Hertzen Oncology Research Institute Moscow (Russia)
Natalia I. Kazachkina, P.A. Hertzen Oncology Research Institute Moscow (Russia)
Galina I. Fomina, P.A. Hertzen Oncology Research Institute Moscow (Russia)
Larisa A. Shitova, P.A. Hertzen Oncology Research Institute Moscow (Russia)
Natalia N. Zharkova, General Physics Institute (Russia)


Published in SPIE Proceedings Vol. 2924:
Photochemotherapy: Photodynamic Therapy and Other Modalities II
Stanley B. Brown; Benjamin Ehrenberg; Johan Moan, Editor(s)

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