Share Email Print
cover

Proceedings Paper

Interaction of photosensitizers with membranes of liposomes and of erythrocytes
Author(s): Gennady I. Klebanov; Eugeny Ph. Stranadko; Y. O. Teselkin; Irina V. Babenkova; Tatyana V. Chichuk
Format Member Price Non-Member Price
PDF $14.40 $18.00

Paper Abstract

There was investigated the interaction of two Russian photosensitizers: Photohem (hematoporphyrin derivative, HPD) and Photosense (sulfonated aluminum phthalocyanine, AlPc) with membranes of the liposomes and of the erythrocytes; and effect of laser irradiation (LI) in the presence of HPD and AlPc on lipid peroxidation of liposomes and photosensitized hemolysis of human erythrocytes. There were studied the interaction of HPD and AlPc with membranes of the liposomes and of the erythrocytes by methods of ultra-centrifugation, ultra-filtration, gel-filtration. An increase of hemolysis of erythrocytes in vivo after PDT was found out. It was found out that, photosensitized lipid peroxidation of liposomes and photosensitized hemolysis of human erythrocytes in vivo and in vitro was inhibited by antioxidants (alpha-tocopherol, carotinoids, flavonoids).

Paper Details

Date Published: 4 December 1996
PDF: 7 pages
Proc. SPIE 2924, Photochemotherapy: Photodynamic Therapy and Other Modalities II, (4 December 1996); doi: 10.1117/12.260758
Show Author Affiliations
Gennady I. Klebanov, Russian State Medical Univ. (Russia)
Eugeny Ph. Stranadko, State Research Ctr. for Laser Medicine (Russia)
Y. O. Teselkin, Russian State Medical Univ. (Russia)
Irina V. Babenkova, Russian State Medical Univ. (Russia)
Tatyana V. Chichuk, State Research Ctr. for Laser Medicine (Russia)


Published in SPIE Proceedings Vol. 2924:
Photochemotherapy: Photodynamic Therapy and Other Modalities II
Stanley B. Brown; Benjamin Ehrenberg; Johan Moan, Editor(s)

© SPIE. Terms of Use
Back to Top