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Proceedings Paper

Cyclic accumulation strategies for polyphasic photoimmunotherapy using the biotin-avidin system
Author(s): Joerg G. Moser; Marina V. Demcheva; Alexander P. Savitzki; Gelii V. Ponomarev; Eugeny A. Lukyanets
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Paper Abstract

Polybiotinylated porphyrinoids and linear alkyl-dibiotins were used to describe accumulation behavior of avidin and POD-labelled avidin on tumor cells preincubated with biotinylated monoclonal antibodies. The accumulation behavior followed more a liner than a formerly postulated branched pattern. This allows for us to calculate necessary repeats of accumulation in order to acquire the necessary amount of sensitizer molecules per tumor cell at low concentration of tumor specific marker molecules at the cell surface.

Paper Details

Date Published: 4 December 1996
PDF: 8 pages
Proc. SPIE 2924, Photochemotherapy: Photodynamic Therapy and Other Modalities II, (4 December 1996); doi: 10.1117/12.260750
Show Author Affiliations
Joerg G. Moser, Institute of Laser Medicine/Heinrich-Heine-Univ. (Germany)
Marina V. Demcheva, Institute of Laser Medicine/Heinrich-Heine-Univ. and Lab. of Molecular Immunology (Russia)
Alexander P. Savitzki, Lab. of Molecular Immunology (Russia)
Gelii V. Ponomarev, Lab. of Biomedical Chemistry (Russia)
Eugeny A. Lukyanets, General Physics Institute (Russia)

Published in SPIE Proceedings Vol. 2924:
Photochemotherapy: Photodynamic Therapy and Other Modalities II
Stanley B. Brown; Benjamin Ehrenberg; Johan Moan, Editor(s)

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