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Proceedings Paper

Interaction of 1540-nm laser radiation with skin (in vivo): morphological and histologic study
Author(s): Alexei V. Lukashev; Boris I. Denker; Victor V. Engovatov; Pavel P. Pashinin; Valery P. Solovyev; Sergey E. Sverchkov
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Paper Abstract

The skin response was studied for different radiant exposure of short and long laser pulses and reaction to multipulse action using Er-glass laser radiation. Lesion ranging from a mild erytherma to tissue coagulation were produced on porcine skin. Radiant exposure producing 50 percent probability of a particular grade of lesion were established. A dependence of ED50 of minimum erythema versus number of pulses and beam cross section were studied. Histological investigation of the damage zone was made for qualitative study of injured skin. The dose-response relationship for producing different grades of burns were determined for energy densities of single laser pulse within the range 0.5-35 J/cm2 and pulse duration 100 ns and 3 ms. The single pulse dose in a chain of repetitive pulses producing minimum erythema were determined for 2n(n equals 1-6) pulses. The minimum reaction of skin on laser irradiance were studied for different beam diameter. The reaction of skin in mostly considered as local super heating. The data obtained are adequate to update safety standards for cutaneous injury within these ranges of radiant exposure and beam spotsize.

Paper Details

Date Published: 5 December 1996
PDF: 11 pages
Proc. SPIE 2923, Laser-Tissue Interaction and Tissue Optics II, (5 December 1996); doi: 10.1117/12.260724
Show Author Affiliations
Alexei V. Lukashev, General Physics Institute (Russia)
Boris I. Denker, General Physics Institute (Russia)
Victor V. Engovatov, Institute of Biophysics (Russia)
Pavel P. Pashinin, General Physics Institute (Russia)
Valery P. Solovyev, Institute of Biophysics (Russia)
Sergey E. Sverchkov, General Physics Institute (Russia)


Published in SPIE Proceedings Vol. 2923:
Laser-Tissue Interaction and Tissue Optics II
Hansjoerg Albrecht; Guy P. Delacretaz; Thomas H. Meier; Rudolf W. Steiner; Lars Othar Svaasand, Editor(s)

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