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Proceedings Paper

Repair of articular cartilage and meniscal tears by photoactive dyes: in-vivo study
Author(s): Millard M. Judy; Robert W. Jackson; Hany R. Nosir; James Lester Matthews; David E. Lewis; Ronald E. Utecht; Dongwu Yuan
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Paper Abstract

We describe healing results of our 6 month study of a repair procedure which evokes the healing response in meniscal tears and partial thickness defects in articular cartilage by a non-thermal tissue sparing photochemical weld using 1,8-naphthalimide dyes. Welds of incisional flaps in adult sheep meniscus and femoral articular cartilage were made using the dye MBM Gold 012011012 at 12 mM in PBS, 457.9nm Argon ion laser radiation at 800 mW/cm2, 7.5 minutes with approximately 1 kg/cm2 externally applied pressure. Gross appearance of tissues in all welded knees appeared normal. Hematoxylin and eosin stained sections disclosed close bonding of welded areas and continuing healing response as cellular recruitment.

Paper Details

Date Published: 3 December 1996
PDF: 5 pages
Proc. SPIE 2922, Laser Applications in Medicine and Dentistry, (3 December 1996); doi: 10.1117/12.260707
Show Author Affiliations
Millard M. Judy, Baylor Research Institute and Microbiomed Corp. (United States)
Robert W. Jackson, Baylor Univ. Medical Ctr. (United States)
Hany R. Nosir, Baylor Univ. Medical Ctr. (United States)
James Lester Matthews, Baylor Research Institute and Microbiomed Corp. (United States)
David E. Lewis, MicroBioMed Corp. and South Dakota State Univ. (United States)
Ronald E. Utecht, Microbiomed Corp. and South Dakota State Univ. (United States)
Dongwu Yuan, Microbiomed Corp. (United States)


Published in SPIE Proceedings Vol. 2922:
Laser Applications in Medicine and Dentistry
Gregory B. Altshuler; Fausto Chiesa; Herbert J. Geschwind; Raimund Hibst; Neville Krasner; Frederic Laffitte; Giulio Maira; Reinhard Neumann; Roberto Pini; Hans-Dieter Reidenbach; Andre Roggan; Montserrat Serra I Mila, Editor(s)

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