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Proceedings Paper

Investigation of local heterogeneity of hbO2 and hb in working dog heart in situ under isovolemic hemodilution and critical coronary stenosis
Author(s): Alfons Krug; Manfred D. Kessler; Raja Khuri; Robert Lust; Randolph Chitwood
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Paper Abstract

A tissue spectrophotometer (EMPHO II) working with 70 micrometer micro lightguide sensors enables recording of spectra in the visible wavelength range (500 - 630 nm). During an initial period arterial hypoxia and hyperoxia were induced on working dog heart by mechanical ventilation with oxygen fractions (fiO2) of 0.1 and 0.5. Under these conditions the effects of low and high fiO2 on oxygenation distribution of intracapillary hemoglobin were investigated. In the second part of the experiment the relation between systemic hematocrit, local hemoglobin concentration, local hemoglobin oxygenation and the oxygen regulation mechanism were studied in detail. In the final part of the experiment the effect of critical coronary stenosis on hb and hbO2 was measured. Critical stenosis was achieved by partial clamping of the left anterior coronary artery (LAD).

Paper Details

Date Published: 11 December 1996
PDF: 11 pages
Proc. SPIE 2927, Optical and Imaging Techniques for Biomonitoring II, (11 December 1996); doi: 10.1117/12.260636
Show Author Affiliations
Alfons Krug, Institut fuer Physiologie und Kardiologie/Univ. Erlangen-Nuernberg (Germany)
Manfred D. Kessler, Institut fuer Physiologie und Kardiologie/Univ. Erlangen-Nuernberg (Germany)
Raja Khuri, East Carolina Univ. (United States)
Robert Lust, East Carolina Univ. (United States)
Randolph Chitwood, East Carolina Univ. (United States)


Published in SPIE Proceedings Vol. 2927:
Optical and Imaging Techniques for Biomonitoring II
Hans-Jochen Foth; Renato Marchesini; Halina Podbielska, Editor(s)

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