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Proceedings Paper

GaAs/AlGaAs-based Mach-Zehnder interferometer as integrated optical immunosensor
Author(s): Bernd Maisenhoelder; Hans P. Zappe; Rino E. Kunz; Peter Riel; Michael Moser; Gert L. Duveneck
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Paper Abstract

System miniaturization is a key issue in further development of integrated optical sensors. We present an integrated optical GaAs/AlGaAs-based Mach-Zehnder interferometer with a 2 mm long TiO2 on SiO2 embedded waveguide sensor pad and its performance as a bioaffinity sensor. Preliminary experiments to evaluate the performance of our Mach-Zehnder interferometer device were done by studying the binding of immunoglobulin (IgG) to protein A. The current resolution limit of IgG surface coverage is 3 pg/mm2, corresponding to less than 1/1600 of a saturated IgG monolayer. Since the design of the basic GaAs/AlGaAs waveguide structure is fully compatible with monolithic integration of lasers, modulators and detectors, improved performance can be expected from integration of these optoelectronic components on the same chip.

Paper Details

Date Published: 26 November 1996
PDF: 9 pages
Proc. SPIE 2928, Biomedical Systems and Technologies, (26 November 1996); doi: 10.1117/12.259972
Show Author Affiliations
Bernd Maisenhoelder, Paul Scherrer Institute (Switzerland)
Hans P. Zappe, Paul Scherrer Institute (Switzerland)
Rino E. Kunz, Paul Scherrer Institute (Switzerland)
Peter Riel, Paul Scherrer Institute (Switzerland)
Michael Moser, Paul Scherrer Institute (Switzerland)
Gert L. Duveneck, Ciba-Geigy Ltd. (Switzerland)

Published in SPIE Proceedings Vol. 2928:
Biomedical Systems and Technologies
Nathan I. Croitoru; Martin Frenz; Terence A. King; Riccardo Pratesi; Anna Maria Verga Scheggi; Stefan Seeger; Otto S. Wolfbeis, Editor(s)

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