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Proceedings Paper

Novel generation of luminescence-based biosensors: single-mode planar waveguide sensors
Author(s): Gert L. Duveneck; Michael Pawlak; Dieter Neuschaefer; Wolfgang Budach; Markus Ehrat
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Paper Abstract

First results with a new generation of bioaffinity sensors based on luminescence excitation using single-mode planar waveguides are presented. Planar waveguides show superior physical characteristics, concerning sensitivity and required sample volumes, and can principally be fabricated in low-costs mass production processes. Additionally, they allow for different detection geometries, e.g., different configurations of fluorescence detection and simultaneous determination of the transmitted excitation light. The transducer characteristics, possible detection geometries and our present experimental configuration are explained. Results with different bioaffinity systems applied on the novel transducer generation are presented, demonstrating the capability of detecting attomole amounts of analytes within a few minutes.

Paper Details

Date Published: 26 November 1996
PDF: 12 pages
Proc. SPIE 2928, Biomedical Systems and Technologies, (26 November 1996); doi: 10.1117/12.259950
Show Author Affiliations
Gert L. Duveneck, Ciba-Geigy Ltd. (Switzerland)
Michael Pawlak, Ciba-Geigy Ltd. (Switzerland)
Dieter Neuschaefer, Ciba-Geigy Ltd. (Switzerland)
Wolfgang Budach, Ciba-Geigy Ltd. (Switzerland)
Markus Ehrat, Ciba-Geigy Ltd. (Switzerland)

Published in SPIE Proceedings Vol. 2928:
Biomedical Systems and Technologies
Nathan I. Croitoru; Martin Frenz; Terence A. King; Riccardo Pratesi; Anna Maria Verga Scheggi; Stefan Seeger; Otto S. Wolfbeis, Editor(s)

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