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Simultaneous micro-PET imaging of F-18 and I-124 with correction for triple-random coincidences
Author(s): Stephen C. Moore; Srilalan Krishnamoorthy; Eric Blankemeyer; Sean D. Carlin; Joel S. Karp; Scott D. Metzler
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Paper Abstract

Positron emission tomographic (PET) images of two radiopharmaceuticals may be obtained simultaneously if one tracer is a standard β+ emitter, while the other also emits prompt gammas that can be used to separate images of the two tracers. We developed and tested an approach to correct simultaneously acquired F-18 and I-124 μPET images for triple-random events that contaminate the desired β+γ triples from I-124. The background compartment of a NEMA-NU4 phantom was filled with approximately equal F-18 and I-124 activities. One of the two smaller cylinders contained a 4.8-times higher concentration of I-124 only; the other contained a 2.8-times higher concentration of F-18 only. List-mode data were acquired on a Molecubes b-CUBE scanner at 0.34h, 4.3h, and 72.2h after phantom filling. After triple-random and crosscontamination correction, the absolute bias of the activity concentration measured in images of the background compartment was ≤2.1% for F-18 and ≤6.8% for I-124. The ratios of hot tube-to-background I-124 concentration underestimated the true ratios by 16.2%, 10.4%, and 9.5% for the three scans; the F-18 ratios overestimated the true ratios by 10.4% and 3.9% for the two scans with F-18. Triple-random correction is important and useful for simultaneous F-18 + I-124 μPET imaging.

Paper Details

Date Published: 28 May 2019
PDF: 5 pages
Proc. SPIE 11072, 15th International Meeting on Fully Three-Dimensional Image Reconstruction in Radiology and Nuclear Medicine, 110720I (28 May 2019); doi: 10.1117/12.2534905
Show Author Affiliations
Stephen C. Moore, Univ. of Pennsylvania (United States)
Srilalan Krishnamoorthy, Univ. of Pennsylvania (United States)
Eric Blankemeyer, Univ. of Pennsylvania (United States)
Sean D. Carlin, Univ. of Pennsylvania (United States)
Joel S. Karp, Univ. of Pennsylvania (United States)
Scott D. Metzler, Univ. of Pennsylvania (United States)


Published in SPIE Proceedings Vol. 11072:
15th International Meeting on Fully Three-Dimensional Image Reconstruction in Radiology and Nuclear Medicine
Samuel Matej; Scott D. Metzler, Editor(s)

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