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Laser-induced focused ultrasound for noninvasive sonothrombolysis using candle soot polymer nanocomposite-coated photoacoustic lens
Author(s): Guangxin Ding; Hui Xia
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Paper Abstract

In this paper, a concave carbon-based polymer nanocomposite film was developed for high-amplitude focused ultrasound. The composite films consisting of candle soot nanoparticles (CSNPs) and elastomeric polymers were used as the high-frequency optoacoustic sources. To generated focused ultrasound, these composite films were formed on concave optical lens. A focal waveform with peak to peak pressure of ~45 MPa was achieved at the focal point. The prototyped laser-induced focused ultrasound (LIFU) was applied with noninvasive sonothrombolysis in vitro. For enhanced cavitation effect, we demonstrated a spatio-temporal superposition approach of LIFU treatment in conjunction with low-frequency focused ultrasound from a piezoelectric ultrasound transducer. The in vitro results showed that dualfrequency excitation ultrasound treatment can achieve the sonothrombolysis efficiency of approximately 28% in half of an hour (2 mg/min), suggesting that LIFU generated from composite films may be promising in precision sonothrombolysis.

Paper Details

Date Published: 17 May 2019
PDF: 7 pages
Proc. SPIE 11170, 14th National Conference on Laser Technology and Optoelectronics (LTO 2019), 1117023 (17 May 2019); doi: 10.1117/12.2533587
Show Author Affiliations
Guangxin Ding, Institute of Electrical Engineering (China)
Univ. of Chinese Academy of Science (China)
Hui Xia, Institute of Electrical Engineering (China)


Published in SPIE Proceedings Vol. 11170:
14th National Conference on Laser Technology and Optoelectronics (LTO 2019)
Jianqiang Zhu; Weibiao Chen; Zhenxi Zhang; Minlin Zhong; Pu Wang; Jianrong Qiu, Editor(s)

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