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Photoacoustic computed tomography for joint reconstruction of initial pressure and sound speed in vivo using a feature coupling method
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Paper Abstract

Photoacoustic imaging relies on diffused photons for optical contrast, and diffracted ultrasound for high resolution. As a tomographic imaging modality, often times an inverse problem of acoustic diffraction needs to be solved to reconstruct a photoacoustic image. The inverse problem is complicated by the fact that the acoustic properties, including the speed of sound distribution, in the image field of view are unknown. During reconstruction, subtle changes of the speed of sound in the acoustic ray path may accumulate and give rise to noticeable blurring in the image. Thus, in addition to the ultrasound detection bandwidth, inaccurate acoustic modeling, especially the unawareness of the speed of sound, defines the image resolution and influences image quantification. Here, we proposed a method termed feature coupling to jointly reconstruct the speed of sound distribution and a photoacoustic image with improved sharpness, at no additional hardware cost. In vivo experiments demonstrated the effectiveness and reliability of our method.

Paper Details

Date Published: 19 July 2019
PDF: 3 pages
Proc. SPIE 11077, Opto-Acoustic Methods and Applications in Biophotonics IV, 110770D (19 July 2019); doi: 10.1117/12.2531541
Show Author Affiliations
Chuangjian Cai, Tsinghua Univ. (China)
Xuanhao Wang, Tsinghua Univ. (China)
Kexin Deng, Tsinghua Univ. (China)
Jianwen Luo, Tsinghua Univ. (China)
Cheng Ma, Tsinghua Univ. (China)


Published in SPIE Proceedings Vol. 11077:
Opto-Acoustic Methods and Applications in Biophotonics IV
Vasilis Ntziachristos; Roger Zemp, Editor(s)

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