Share Email Print
cover

Proceedings Paper • new

Modeling of hyperthermia induced by functionalized gold nanorods bound to Staphylococcus aureus under NIR laser radiation
Author(s): Alexander N. Yakunin; Sergey V. Zarkov; Yuri A. Avetisyan; Garif G. Akchurin; Georgy G. Akchurin Jr.; Elena S. Tuchina; Valery V. Tuchin
Format Member Price Non-Member Price
PDF $14.40 $18.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

In this paper, a theoretical model of the formation of a local temperature field in suspensions of microorganisms with embedded plasmonic gold nanorods under irradiation by low-intensity NIR laser light was considered. The results of numerical modeling of the optical properties of plasmon nanorods used in the experiments, and the results of multiscale modeling of the parameters of local hyperthermia with various types of distribution of the concentration of plasmon nanoparticles are presented. Found that the process of concentration of nanoparticles, functionalized with human immune globulins IgA and IgG, around the cells of microorganisms with the formation of "clouds" leads to the appearance of a microscale zone of elevated temperature. This ensures a synergistic effect of a multiplicative increase in the volume of the hyperthermia zone. The results of numerical simulation provide a justification for the experimentally observed increase in the bacterium killing ability at laser hyperthermia of the cellular environment doped with functionalized nanoparticles, without a noticeable increment in the recorded average sample temperature when irradiated with a low intensity laser beam of around 100 mW/cm2.

Paper Details

Date Published: 3 June 2019
PDF: 10 pages
Proc. SPIE 11065, Saratov Fall Meeting 2018: Optical and Nano-Technologies for Biology and Medicine, 1106516 (3 June 2019); doi: 10.1117/12.2531440
Show Author Affiliations
Alexander N. Yakunin, Institute of Precision Mechanics and Control (Russian Federation)
Sergey V. Zarkov, Institute of Precision Mechanics and Control (Russian Federation)
Yuri A. Avetisyan, Institute of Precision Mechanics and Control (Russian Federation)
Garif G. Akchurin, Institute of Precision Mechanics and Control (Russian Federation)
Saratov State Univ. (Russian Federation)
Georgy G. Akchurin Jr., Institute of Precision Mechanics and Control (Russian Federation)
Saratov State Univ. (Russian Federation)
Elena S. Tuchina, Saratov State Univ. (Russian Federation)
Valery V. Tuchin, Institute of Precision Mechanics and Control (Russian Federation)
Saratov State Univ. (Russian Federation)
National Research Tomsk State Univ. (Russian Federation)


Published in SPIE Proceedings Vol. 11065:
Saratov Fall Meeting 2018: Optical and Nano-Technologies for Biology and Medicine
Elina A. Genina; Valery V. Tuchin, Editor(s)

© SPIE. Terms of Use
Back to Top