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Bringing third and second harmonic generation microscopy into the clinic for the assessment of fresh lung tissue
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Paper Abstract

Third and second harmonic generation (THG/SHG) microscopy is a novel imaging technique that has been suggested as a promising clinical tool, mainly for cancer diagnosis. Here, we test for the first time a compact, transportable ex-vivo THG/SHG microscope (Tritos Diagnostics B.V.) for clinical use. In lung surgery, immediate feedback on the nature of the excised tissue is important. We will present the first results of an ongoing study in which we image both lung tumor tissue immediately after excision and frozen section biopsies, and compare the images to the golden standard histology. Prior to this study, we performed a set of experiments collecting 3D images of mouse lung tissue to show that the combination of THG and SHG microscopy reveals key lung morphology components.

Paper Details

Date Published: 22 July 2019
PDF: 3 pages
Proc. SPIE 11079, Medical Laser Applications and Laser-Tissue Interactions IX, 110790J (22 July 2019); doi: 10.1117/12.2527899
Show Author Affiliations
Laura M. G. van Huizen, Vrije Univ. Amsterdam (Netherlands)
Daniëlle Seinstra, Amsterdam UMC (Netherlands)
Chris Dickhoff, Amsterdam UMC (Netherlands)
Teodora Radonic, Amsterdam UMC (Netherlands)
Idris Bahce, Amsterdam UMC (Netherlands)
Frank van Mourik, Tritos Diagnostics B.V. (Netherlands)
Jouke T. Annema, Amsterdam UMC (Netherlands)
Johannes M. A. Daniels, Amsterdam UMC (Netherlands)
Wim-Jan P. van Boven, Amsterdam UMC (Netherlands)
Marie Louise Groot, Vrije Univ. Amsterdam (Netherlands)


Published in SPIE Proceedings Vol. 11079:
Medical Laser Applications and Laser-Tissue Interactions IX
Lothar D. Lilge; Carsten M. Philipp, Editor(s)

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