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Photodynamic therapy of brain tumor stem cells overcomes drug-resistance in preclinical models (Conference Presentation)
Author(s): Bryan Q. Spring

Paper Abstract

Standard chemoradiation often enriches drug-resistant tumor cell populations that can lead to recurrent and treatment-refractory disease. For instance, preclinical models of several cancers suggest that the cancer stem cell subpopulation becomes enriched and re-populates the tumor milieu following conventional therapies. Here, we show evidence that photodynamic therapy (PDT) is effective against several patient-derived glioblastoma stem cell cultures. Moreover, sub-lethal PDT results in re-sensitization of cancer cell phenotypes with induced drug-resistance to chemotherapy. This talk will also introduce some of our efforts to establish a new program aimed at developing personalized and targeted PDT to overcome drug-resistance.

Paper Details

Date Published: 14 August 2019
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Proc. SPIE 11070, 17th International Photodynamic Association World Congress, 110701E (14 August 2019); doi: 10.1117/12.2527769
Show Author Affiliations
Bryan Q. Spring, Northeastern Univ. (United States)


Published in SPIE Proceedings Vol. 11070:
17th International Photodynamic Association World Congress
Tayyaba Hasan, Editor(s)

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