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Depth-resolved attenuation coefficient estimation for skin cancer assessment with optical coherence tomography
Author(s): Eusebio Real; Gema Pérez Paredes; José M. López Higuera; Olga M. Conde
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Paper Abstract

Optical Coherence Tomography (OCT) is nowadays being widely employed as a diagnostic tool for skin cancer. It can produce feedback on tissue morphology alterations produced by different pathologies. OCT images are mainly produced by differences in refractive index and attenuation coefficient, providing in-depth information. Intensity OCT images display the effect of tissue alterations on backscattered light, but it does not represent real physical magnitude. In a number of occasions, morphology alteration events within the same tissue type, produce intensity variations in OCT images that can be misclassified as different tissue component. The estimation of depth-resolved attenuation coefficient improves tissue contrast, helping to identify tissue identity and isolating the effect of disordered structures of the same tissue. The proposed methodology shows that melanoma and Basal Cell Carcinoma (BCC) pathologies exhibit different optical parameters in depth. This enhances the identification of subsurface skin features.

Paper Details

Date Published: 19 July 2019
PDF: 3 pages
Proc. SPIE 11078, Optical Coherence Imaging Techniques and Imaging in Scattering Media III, 1107812 (19 July 2019); doi: 10.1117/12.2527255
Show Author Affiliations
Eusebio Real, Univ. de Cantabria (Spain)
Instituto de Investigación Marqués de Valdecilla (Spain)
Gema Pérez Paredes, Univ. Hospital Marques de Valdecilla (Spain)
José M. López Higuera, Univ. de Cantabria (Spain)
Instituto de Investigación Marqués de Valdecilla (Spain)
Ctr. de Investigación Biomédica en Red Engineering (Spain)
Olga M. Conde, Univ. de Cantabria (Spain)
Instituto de Investigación Marqués de Valdecilla (Spain)
Ctr. de Investigación Biomédica en Red Engineering (Spain)


Published in SPIE Proceedings Vol. 11078:
Optical Coherence Imaging Techniques and Imaging in Scattering Media III
Maciej Wojtkowski; Stephen A. Boppart; Wang-Yuhl Oh, Editor(s)

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