Share Email Print
cover

Proceedings Paper • new

Laser irradiation induces mitochondrial dysfunction in hepatic cells
Author(s): Anna Lynnyk; Barbora Smolková; Mariia Uzhytchak; Daria Egorova; Andrei Kulikov; Mariia Lunova; Šárka Kubinová; Alexandr Dejneka; Oleg Lunov
Format Member Price Non-Member Price
PDF $17.00 $21.00

Paper Abstract

Laser irradiation has been recognized as a promising tool across a number of biomedical applications. However, understanding the molecular mechanisms and cellular responses remains incomplete. Here, we investigated the mechanism involved in the apoptotic process in human hepatic cells under laser irradiation. Our data show that the laser-mediated alternation of mitochondrial membrane potential leads apoptosis in Huh7 and Alexander cells. Contrary, HepG2 cells are resistant to laser induced cell death. The observed link between mitochondrial membrane potential and cytotoxicity could be a fundamental phenomenon in laser-induced cell apoptosis.

Paper Details

Date Published: 22 July 2019
PDF: 4 pages
Proc. SPIE 11079, Medical Laser Applications and Laser-Tissue Interactions IX, 1107911 (22 July 2019); doi: 10.1117/12.2527110
Show Author Affiliations
Anna Lynnyk, Institute of Physics of the CAS, v.v.i. (Czech Republic)
Barbora Smolková, Institute of Physics of the CAS, v.v.i. (Czech Republic)
Mariia Uzhytchak, Institute of Physics of the CAS, v.v.i. (Czech Republic)
Daria Egorova, ITMO Univ. (Russian Federation)
Andrei Kulikov, ITMO Univ. (Russian Federation)
Mariia Lunova, Institute for Clinical and Experimental Medicine (Czech Republic)
Šárka Kubinová, Institute of Experimental Medicine (Czech Republic)
Alexandr Dejneka, Institute of Physics of the CAS, v.v.i. (Czech Republic)
Oleg Lunov, Institute of Physics of the CAS, v.v.i. (Czech Republic)


Published in SPIE Proceedings Vol. 11079:
Medical Laser Applications and Laser-Tissue Interactions IX
Lothar D. Lilge; Carsten M. Philipp, Editor(s)

© SPIE. Terms of Use
Back to Top