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Comparative analysis of single- and dual-wavelength low dose photodynamic therapy regimens
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Paper Abstract

Dual-wavelength photodynamic therapy is a photodynamic therapy (PDT) modality combining therapeutic effects of irradiation at two wavelengths of different region of visible range. In this paper we report on comparative analysis of single- and dual-wavelength PDT regimes based on multimodal optical monitoring of tissue response with histologic verification. Morphological and functional tissue responses to PDT procedure with chlorin-based photosensitizer (PS) were studied at the normal skin of a rabbit ear inner surface. Multimodal optical monitoring was performed by OCT and dual-wavelength fluorescence technique. The studied doses vary from 50 to 150 J/cm2 delivered separately at 405 or 660 nm, or at both wavelengths together in the equal dose.

Paper Details

Date Published: 22 July 2019
PDF: 3 pages
Proc. SPIE 11079, Medical Laser Applications and Laser-Tissue Interactions IX, 110791K (22 July 2019); doi: 10.1117/12.2527108
Show Author Affiliations
Daria A. Kurakina, Institute of Applied Physics (Russian Federation)
Aleksandr V. Khilov, Institute of Applied Physics (Russian Federation)
Maria A. Shakhova, Institute of Applied Physics (Russian Federation)
Privolzhsky Research Medical Univ. (Russian Federation)
Natalia Yu. Orlinskaya, Privolzhsky Research Medical Univ. (Russian Federation)
Mikhail Yu. Kirillin, Institute of Applied Physics (Russian Federation)


Published in SPIE Proceedings Vol. 11079:
Medical Laser Applications and Laser-Tissue Interactions IX
Lothar D. Lilge; Carsten M. Philipp, Editor(s)

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