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Monitoring temperature induced phase changes in subcutaneous fatty tissue using an astigmatism corrected dynamic needle probe
Author(s): H. Schulz-Hildebrandt; N. Meyer-Schell; M. Casper; M. Evers; R. Birngruber; D. Manstein; G. Hüttmann
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Paper Abstract

Cryolipolysis has become a popular non-invasive method of reducing excess fat by cooling. However, the results vary as metabolism, gender and diet may affect the freezing point of human subcutaneous fat. To increase the success for all patients, it is essential to better understand the process of cryolipolysis in vivo. Therefore, we have developed a side-facing needle probe with an outer diameter of 390 μm achieving a lateral resolution of 10 μm at a working distance of 1.5 mm. To obtain a spatially resolved visualization of the immediate processes involve in cryolipolysis, cross-sectional images was obtained by moving the needle probe back and forth in a transparent catheter. At the tip, the transparent catheter was equipped with a lancet for smoothly penetrating through the skin. By a rigorous design including optical wave simulation and by a careful combination of different materials astigmatic aberrations were avoided. Ex vivo measurements on subcutaneous porcine fat were performed to confirm, that imaging with the needle probe is a suitable method for investigating phase changes.

Paper Details

Date Published: 19 July 2019
PDF: 3 pages
Proc. SPIE 11073, Clinical and Preclinical Optical Diagnostics II, 110730L (19 July 2019); doi: 10.1117/12.2527087
Show Author Affiliations
H. Schulz-Hildebrandt, Univ. zu Lübeck (Germany)
German Ctr. for Lung Research (Germany)
Medical Laser Ctr. Lübeck (Germany)
N. Meyer-Schell, Univ. zu Lübeck (Germany)
M. Casper, Massachusetts General Hospital, Harvard Medical School (United States)
M. Evers, Massachusetts General Hospital, Harvard Medical School (United States)
R. Birngruber, Univ. zu Lübeck (Germany)
German Ctr. for Lung Research (Germany)
D. Manstein, Massachusetts General Hospital, Harvard Medical School (United States)
G. Hüttmann, Univ. zu Lübeck (Germany)
German Ctr. for Lung Research (Germany)
Medical Laser Ctr. Lübeck (Germany)


Published in SPIE Proceedings Vol. 11073:
Clinical and Preclinical Optical Diagnostics II
J. Quincy Brown; Ton G. van Leeuwen, Editor(s)

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