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A new multichannel broadband NIRS system for quantitative monitoring of brain hemodynamics and metabolism during seizures
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Paper Abstract

We present a newly developed multichannel broadband NIRS (or bNIRS) system that has the capacity to measure changes in light attenuation of 308 NIR wavelengths (610nm to 918nm) simultaneously over 16 different brain locations. To achieve this the instrument uses a lens based spectrometer with a front-illuminated CCD that has a sensor size of 26.8x26mm. This large CCD detector allows the simultaneous binning of 16 detector fibres. The software uses the UCLn algorithm to quantify the changes in oxy-, deoxy- haemoglobin concentration (HbO2, HHb) and oxidised cytochrome-coxidase (oxCCO) simultaneously over 16 different brain locations with 1second sampling rate. We demonstrate the use of the instrument in quantifying brain tissue oxygenation and metabolic activity simultaneously with electrical changes as measured with EEG in children with seizures.

Paper Details

Date Published: 11 July 2019
PDF: 3 pages
Proc. SPIE 11074, Diffuse Optical Spectroscopy and Imaging VII, 1107406 (11 July 2019); doi: 10.1117/12.2527067
Show Author Affiliations
Isabel De Roever, Univ. College London (United Kingdom)
Aikaterini Vezyroglou, Univ. College London (United Kingdom)
Great Ormond Street Hospital (United Kingdom)
Peter Hebden, Univ. College London (United Kingdom)
Rachel Thornton, Great Ormond Street Hospital (United Kingdom)
Alan Worley, Great Ormond Street Hospital (United Kingdom)
Mariana Alves, Great Ormond Street Hospital (United Kingdom)
Emma Dean, Great Ormond Street Hospital (United Kingdom)
Gemma Bale, Univ. College London (United Kingdom)
Paola Pinti, Univ. College London (United Kingdom)
J. Helen Cross, Univ. College London (United Kingdom)
Great Ormond Street Hospital (United Kingdom)
Ilias Tachtsidis, Univ. College London (United Kingdom)


Published in SPIE Proceedings Vol. 11074:
Diffuse Optical Spectroscopy and Imaging VII
Hamid Dehghani; Heidrun Wabnitz, Editor(s)

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