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In vivo time-domain diffuse correlation spectroscopy of the human muscle above 1000 nm
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Paper Abstract

Time-domain diffuse correlation spectroscopy (TD-DCS) is an emerging optical technique with the potential to resolve the blood flow (BF) in depth. The first in vivo measurements have been shown recently on humans, however improvements in terms of signal-to-noise ratio (SNR) and depth sensitivity would be beneficial for biological applications. In this contribution, we explore the possibility of in vivo TD-DCS measurements above 1000 nm, and discuss its possible advantages compared to standard wavelengths (i.e. 700-800 nm). In our experimental setup, we exploited a tunable pulsed laser source extended more to the infrared and an InGaAs photomultiplier. Here, we report the results of a cuff occlusion on the forearm of a healthy adult subject at a wavelength of 1000 nm. Compared to the same experiment at standard wavelength (785 nm), the electric-field auto-correlation functions show a slower decay rate during all the experiment (both during and after the occlusion) as expected, suggesting a higher SNR. Even longer wavelengths, for diminishing water absorption, can be obtained through optimization of the laser source and the use of more efficient detectors.

Paper Details

Date Published: 11 July 2019
PDF: 3 pages
Proc. SPIE 11074, Diffuse Optical Spectroscopy and Imaging VII, 110742V (11 July 2019); doi: 10.1117/12.2527065
Show Author Affiliations
L. Colombo, Politecnico di Milano (Italy)
M. Pagliazzi, ICFO - Institut de Ciències Fotòniques (Spain)
S. Konugolu Venkata Sekar, Politecnico di Milano (Italy)
D. Contini, Politecnico di Milano (Italy)
A. Dalla Mora, Politecnico di Milano (Italy)
L. Spinelli, CNR-Istituto di Fotonica e Nanotecnologie (Italy)
A. Torricelli, Politecnico di Milano (Italy)
CNR-Istituto di Fotonica e Nanotecnologie (Italy)
T. Durduran, ICFO - Institut de Ciències Fotòniques (Spain)
Institució Catalana de Recerca i Estudis Avançats (Spain)
A. Pifferi, Politecnico di Milano (Italy)
CNR-Istituto di Fotonica e Nanotecnologie (Spain)


Published in SPIE Proceedings Vol. 11074:
Diffuse Optical Spectroscopy and Imaging VII
Hamid Dehghani; Heidrun Wabnitz, Editor(s)

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