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Red and blue light photodynamic therapy regimes: optical monitoring and histology studies
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Paper Abstract

In this study we present a complex approach to photodynamic therapy (PDT) with chlorin based photosensitizers including Monte Carlo based planning and prediction of optical diagnostics results, intra-procedure dual-wavelength fluorescence monitoring allowing to evaluate PS accumulation and photobleaching, and monitoring of tissue response with optical coherence tomography (OCT). The approach was employed to compare the effects of different PDT regimens in normal and tumor tissues and the results of non-invasive optical diagnostics were matched with results of histologic examination, including hematoxylin-eosin and Mallory staining. The considered doses are in the range 50-150 J/cm2 for normal tissues and 150-275 J/cm2 for tumor tissues, single wavelength (405 and 660 nm) and dual-wavelength regimes are studied.

Paper Details

Date Published: 22 July 2019
PDF: 3 pages
Proc. SPIE 11079, Medical Laser Applications and Laser-Tissue Interactions IX, 110790R (22 July 2019); doi: 10.1117/12.2527061
Show Author Affiliations
Mikhail Kirillin, Institute of Applied Physics (Russian Federation)
Maria Shakhova, Institute of Applied Physics (Russian Federation)
Privolzhsky Research Medical Univ. (Russian Federation)
Daria Kurakina, Institute of Applied Physics (Russian Federation)
Aleksandr Khilov, Institute of Applied Physics (Russian Federation)
Anna Orlova, Institute of Applied Physics (Russian Federation)
Ekaterina Sergeeva, Institute of Applied Physics (Russian Federation)
Alina Meller, Institute of Applied Physics (Russian Federation)
Privolzhsky Research Medical Univ. (Russian Federation)
Natalia Orlinskaya, Institute of Applied Physics (Russian Federation)
Privolzhsky Research Medical Univ. (Russian Federation)
Ilya Turchin, Institute of Applied Physics (Russian Federation)


Published in SPIE Proceedings Vol. 11079:
Medical Laser Applications and Laser-Tissue Interactions IX
Lothar D. Lilge; Carsten M. Philipp, Editor(s)

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