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Infrared spectroscopy evaluation of burn wound healing: semi-quantitative study
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Paper Abstract

Wound healing is a biological response in order to recover the tissue stability after injury. The impaired healing by third-degree, when the damage achieves the major part of dermis, is defined in four sequential and overlapping phases: Inflammation, transition, proliferative and maturative1. The role of biochemical cascade associated in each phase are still not fully understood, thus systematic evaluations tests are crucial. In fact, the gold standard to interrogate the molecular signature of wound healing is concern on immunohistochemical analysis. This approach tends to be laborious, time-consuming and require multiple assays2. Since Fourier transform infrared spectroscopy (FTIR) has been demonstrated in other studies to provide molecular change report upon biological samples, the present study aims to estimate the feasibility of FTIR to discriminate healthy and burned skin throughout wound stages.

Paper Details

Date Published: 19 July 2019
PDF: 4 pages
Proc. SPIE 11073, Clinical and Preclinical Optical Diagnostics II, 1107304 (19 July 2019); doi: 10.1117/12.2527051
Show Author Affiliations
Pedro A. A. de Castro, Univ. de São Paulo (Brazil)
Denise M. Zezell, Univ. de São Paulo (Brazil)


Published in SPIE Proceedings Vol. 11073:
Clinical and Preclinical Optical Diagnostics II
J. Quincy Brown; Ton G. van Leeuwen, Editor(s)

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