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Time-Resolved multi-wavelength, dual-channel system for diffuse optical spectroscopy: performance assessment
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Paper Abstract

In this paper we present the ex-vivo characterization of a full-custom made multi-wavelength, two channel Time-Resolved Spectroscopy (TRS) module developed with the aim of being integrated in to a multi-modal spectroscopic device. This module overcomes all the main drawbacks of systems based on time-domain techniques such as high complexity and bulkiness while guaranteeing performances comparable to expensive state-of-the-art available devices. Each subcomponent of the module has been tailored and optimized to meet all the above-mentioned requirements. In order to assess and translate the performances of these tools for effective clinical use, we characterized the system following the guidelines of common standardization protocols. By following MEDPHOT guidelines, the linearity and accuracy in retrieving absolute values of absorption and scattering coefficients were determined by means of measurements on homogeneous phantoms. Finally, by means of a mechanically switchable solid inhomogeneous phantom (developed under the nEUROPT project) we simulated the clinical problem of detecting and localizing an absorption perturbation in a homogeneous background with broad applications such as detection of cancer lesions, thyroid, etc.

Paper Details

Date Published: 11 July 2019
PDF: 3 pages
Proc. SPIE 11074, Diffuse Optical Spectroscopy and Imaging VII, 110742Q (11 July 2019); doi: 10.1117/12.2527049
Show Author Affiliations
Marta Zanoletti, Politecnico di Milano (Italy)
Marco Renna, Politecnico di Milano (Italy)
Mauro Buttafava, Politecnico di Milano (Italy)
Anurag Behera, Politecnico di Milano (Italy)
Pranav Lanka, Politecnico di Milano (Italy)
Laura Di Sieno, Politecnico di Milano (Italy)
Alberto Dalla Mora, Politecnico di Milano (Italy)
Alberto Tosi, Politecnico di Milano (Italy)
Davide Contini, Politecnico di Milano (Italy)


Published in SPIE Proceedings Vol. 11074:
Diffuse Optical Spectroscopy and Imaging VII
Hamid Dehghani; Heidrun Wabnitz, Editor(s)

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