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Optical coherence elastography for visualization of spatio-temporal strain dynamics in thermo-mechanical modification of corneal and cartilaginous tissues
Author(s): Vladimir Y. Zaitsev; Alexander A. Sovetsky; Alexander L. Matveyev; Lev A. Matveev; Olga I. Baum
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Paper Abstract

In recent years, an emerging group of therapeutic methods, which can be considered as intermediate between photobiomodulation and coagulative methods, is non-surgical thermo-mechanical reshaping of avascular collagenous biological tissues. It is based on moderate laser-produced heating (below 50-70°C) combined with auxiliary mechanical action on the tissue. For duly chosen parameters, such moderate heating can be biologically non-destructive, so that this technique of laser-assisted modification of collagenous tissues is emerging in clinic for various applications. For example, using such an approach, planar cartilaginous plates can be transformed into annulus-shape implants for otolaryngological operations. Similar microstructural changes occurring in moderately heated cornea open the possibility to modify eye-cornea shape and, consequently, eye refraction, which can be used for non-surgical correction of vision problems. Such applications obviously require detailed understanding of the background thermo-mechanical properties and possibility to precisely control the laser-produced heating and the resultant deformations of the tissue. Recently, progress in the development of optical coherence elastography (OCE), in particular the possibility to obtain high-resolution maps of "instantaneous" and cumulative strains suggests that OCE can be successfully used as a control mean in the novel applications of laser-assisted tissue reshaping. This study reports results on application of phase-sensitive optical coherence elastography for mapping transient thermomechanically-produced strain fields in such biological tissues, as cartilages and cornea subjected to pulse-periodic irradiation with infrared Gaussian laser beam. The developed OCE technique made it possible to demonstrate complex character of the thermo-mechanically produced strains, which is attributed to non-trivial interplay between the spatially non-coinciding temperature increase and thermal stresses.

Paper Details

Date Published: 19 July 2019
PDF: 3 pages
Proc. SPIE 11078, Optical Coherence Imaging Techniques and Imaging in Scattering Media III, 110781O (19 July 2019); doi: 10.1117/12.2526941
Show Author Affiliations
Vladimir Y. Zaitsev, Institute of Applied Physics (Russian Federation)
Alexander A. Sovetsky, Institute of Applied Physics (Russian Federation)
Alexander L. Matveyev, Institute of Applied Physics (Russian Federation)
Lev A. Matveev, Institute of Applied Physics (Russian Federation)
Olga I. Baum, Federal Research Ctr. "Crystallography and Photonics" (Russian Federation)


Published in SPIE Proceedings Vol. 11078:
Optical Coherence Imaging Techniques and Imaging in Scattering Media III
Maciej Wojtkowski; Stephen A. Boppart; Wang-Yuhl Oh, Editor(s)

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